Niflumic acid MedChemExpress (MCE)

Product Name	Niflumic acid
Synonyms	Niflumic acid ACIDUM NIFLUMICUM Niflumic acid solution,100ppm ACIDUMNIFLUMICUM(NIFLUMICACID) Nicotinic acid Solution, 100ppm 2-[3-(Trifluoromethyl)anilino]nicotinic acid 2-(α,α,α-trifluoro-m-toluidino)nicotinic acid Synonyms Niflumic acid ACIDUM NIFLUMICUM Niflumic acid solution,100ppm ACIDUMNIFLUMICUM(NIFLUMICACID) Nicotinic acid Solution, 100ppm 2-[3-(Trifluoromethyl)anilino]nicotinic acid 2-(α,α,α-trifluoro-m-toluidino)nicotinic acid 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid 2-[3-(Trifluoromethyl)-phenyl]aminonicotinic acid 2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinic acid 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate 2-[(3-Trifluoromethylphenyl)amino]nicotinic AcidNiflumic Acid 2-[3-(Trifluoromethyl)anilino]nicotinic acid, 2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid
CAS	4394-00-7
EINECS	224-516-2
Chemical Formula	C13H9F3N2O2
Molecular Weight	282.22
inchi	InChI=1/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)/p-1
Package	10 mM * 1 mL;100 mg
Price	Email to quote
Descriptions	Niflumic acid Niflumic acid MedChemExpress (MCE) HY-B0493 4394-00-7 99.88% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Niflumic acid Niflumic acid MedChemExpress (MCE) HY-B0493 4394-00-7 99.88% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis. Niflumic acid (100 and 200 μM 48 h) combined with Ciglitazone (HY-W011220) exerts cytotoxic effect against A549, H460, and H1299 cells[5]. Niflumic acid (0-300 μM 36 h) combined with Ciglitazone induces apoptosis in A549, H460, and H1299 cells[5]. Niflumic acid (100 μM 30 h) combined with Ciglitazone induces activates caspase-8/Bid/Bax pathway in lung cancer cells[5]. Niflumic acid (30 mg/kg inhalation 2 times in 10 min) inhibits the secretory response of mucus granules in an pig asthma model [8]. COX-2 100 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Criddle, D.N., et al., Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol, 1997. 120(5): p. 813-8. [Content Brief] [2]. Jabeen, T., et al., Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr D Biol Crystallogr, 2005. 61(Pt 12): p. 1579-86. [Content Brief] [3]. Picollo, A., et al., Mechanism of interaction of niflumic acid with heterologously expressed kidney CLC-K chloride channels. J Membr Biol, 2007. 216(2-3): p. 73-82. [Content Brief] [4]. Yuliya V Kucherenko, et al. Niflumic Acid Affects Store-Operated Ca2+-Permeable (SOC) and Ca2+-Dependent K+ and Cl2 Ion Channels and Induces Apoptosis in K562 Cells. J Membr Biol. 2014 Jul 247(7):627-38. [Content Brief] [5]. Byeong Mo Kim, et al. Combined treatment with the Cox-2 inhibitor niflumic acid and PPARc ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells. Cancer Lett. 2011 Jan 28 300(2):134-44. [Content Brief] [6]. Shengqun Luo , et al. Niflumic acid exhibits anti-tumor activity in nasopharyngeal carcinoma cells through affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Int J Clin Exp Pathol [Content Brief] [7]. I Florentin , et al. MODULATION OF IMMUNE RESPONSES IN MICE BY ORAL ADMINISTRATION OF NIFLUMIC ACID. Int J Immunopharmacol. 1989 11(2):173-83. [8]. Mitsuko Kondo , et al. Niflumic Acid Inhibits Goblet Cell Degranulation in a Guinea Pig Asthma Model. Allergol Int. 2012 Mar 61(1):133-42. [Content Brief]
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Last Update	2025-05-21 16:50:25

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