Gimestat MedChemExpress (MCE)

Product Name	GIMERACIL
Synonyms	CDHP gimestat GIMERACIL 5-chloropyridine-2,4-diol 5-Chloro-4-hydroxy-2-pyridone 5-Chloro-2,4-dihydroxypyridine 5-Chloro-4-hydroxy-2(1H)-pyridinone Synonyms CDHP gimestat GIMERACIL 5-chloropyridine-2,4-diol 5-Chloro-4-hydroxy-2-pyridone 5-Chloro-2,4-dihydroxypyridine 5-Chloro-4-hydroxy-2(1H)-pyridinone 2(1H)-Pyridinone, 5-chloro-4-hydroxy- 2(1H)-Pyridinone,5-chloro-4-hydroxy-(9CI)
CAS	103766-25-2
EINECS	1312995-182-4
Chemical Formula	C5H4ClNO2
Molecular Weight	145.54
inchi	InChI=1/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
Package	10 mM * 1 mL;25 mg;50 mg;100 mg;500 mg
Price	Email to quote
Descriptions	Gimeracil Gimeracil MedChemExpress (MCE) HY-17469 103766-25-2 Gimestat 99.72% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Gimeracil Gimeracil MedChemExpress (MCE) HY-17469 103766-25-2 Gimestat 99.72% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). Gimeracil reduces the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1[1]. Gimeracil may enhance the efficacy of radiotherapy through the suppression of HR-mediated DNA repair pathways[1]. Gimeracil pretreatment significantly restrains the formation of radiation-induced foci of Rad51 and RPA, whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2[2]. Gimeracil (2.5-25 mg/kg, orally) may inhibit the rapid repair of X-ray-induced DNA damage in tumors[3]. \| \| \| \| \| \| \| \| \| \| [1]. Masaru Takagi, et al. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. Radiother Oncol. 2010 Aug 96(2):259-66. [Content Brief] [2]. Koh-Ichi Sakata, et al. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Cancer Sci. 2011 Sep 102(9):1712-6. [Content Brief] [3]. Masakazu Fukushima, et al. Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo. Oncol Rep. 2010 Nov 24(5):1307-13. [Content Brief]
Supplier Website	https://www.medchemexpress.com/gimeracil.html
Last Update	2025-05-21 16:50:25

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