LEE011 MedChemExpress (MCE)

Product Name	LEE011
Synonyms	LEE011 Ribociclib LEE-011, Ribociclib 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Synonyms LEE011 Ribociclib LEE-011, Ribociclib 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]- 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide LEE 011 LEE 011 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS	1211441-98-3
EINECS	1592732-453-0
Chemical Formula	C23H30N8O
Molecular Weight	434.54
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Package	10 mM * 1 mL;2 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Ribociclib Ribociclib MedChemExpress (MCE) HY-15777 1211441-98-3 LEE011 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US Descriptions Ribociclib Ribociclib MedChemExpress (MCE) HY-15777 1211441-98-3 LEE011 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US may vary elsewhere. RRibociclib (LEE011) is an ATP-competitive and orally active CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. Ribociclib (500 nM 6 days) inhibits the growth of neuroblastoma cell lines BE2C and IMR5[2]. Ribociclib (200 mg/kg p.o. 21 days) delays tumor growth in CB17-immunodeficient BE2C or 1643 xenograft mice[2]. CDK4 10 nM (IC50) CDK6 39 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1 21(13):2905-10. [Content Brief] [2]. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15 19(22):6173-82. [Content Brief]
Supplier Website	https://www.medchemexpress.com/LEE011.html
Last Update	2025-05-21 16:50:25

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