AST-1306 (TsOH) MedChemExpress (MCE)

Product Name	AST-1306 TsOH
Synonyms	AST-6 AST-1306 AST-1306 TsOH AST-1306 (TsOH) AST1306 tosilate AST 1306 tosylate AST1306 (p-Toluenesulfonic acid) Synonyms AST-6 AST-1306 AST-1306 TsOH AST-1306 (TsOH) AST1306 tosilate AST 1306 tosylate AST1306 (p-Toluenesulfonic acid) AST 1306 (p-Toluenesulfonic acid) AST-1306 (p-Toluenesulfonic acid) N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide 4-methylbenzenesulfonate
CAS	1050500-29-2
EINECS
Chemical Formula	C31H26ClFN4O5S
Molecular Weight	621.0783432
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Allitinib tosylate Allitinib tosylate MedChemExpress (MCE) HY-13427 1050500-29-2 AST-1306 (TsOH) 99.83% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Allitinib tosylate Allitinib tosylate MedChemExpress (MCE) HY-13427 1050500-29-2 AST-1306 (TsOH) 99.83% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Allitinib tosylate (AST-1306 (TsOH)) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. Allitinib tosylate also inhibits ErbB4 with an IC50 of 0.8 nM. Allitinib tosylate is an anilino-quinazoline compound and has anti-cancer activity AST1306 tosylate (AST-1306 (TsOH) 0.19-6.25 μM 72 hours) induces a significant, concentration-dependent inhibition of the growth of HIH3T3-EGFR T790M/L858R cells[1]. AST1306 tosylate inhibits the activation of tyrosine kinases and downstream signaling pathways in A549 cells, Calu-3 cells and SK-OV-3 cells. AST1306 tosylate dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells[1]. AST1306 tosylate (0.1, 0.5, 1.0, 5.0 μM) can dramatically inhibit the growth of both tumor cells on soft agar, and SK-OV-3 cells exhibited much more sensitivity than that of A549 cells[1]. AST1306 tosylate (0.001-1.0 μM 4 hours) is more than 3000-fold selective for ErbB family kinases over other kinase families[1]. AST1306 tosylate potently inhibits the EGFR T790M/L858R double mutant, exhibiting an IC50 value of 12±2 nmol/L[1]. AST1306 tosylate (AST-1306 (TsOH) p.o. 25-100 mg/kg twice daily for 28 days) causes a dramatic suppression of tumor growth in SK-OV-3 and Calu-3 xenograft models[1]. EGFR 0.5 nM (IC50) ErbB2 3 nM (IC50) EGFRL858R/T790M 12 nM (IC50) ErbB4 0.8 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Xie H, Lin L, Tong L et al. AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. PLoS One. 2011 6(7):e21487. [Content Brief]
Supplier Website	https://www.medchemexpress.com/ast-1306-tsoh.html
Last Update	2025-05-21 16:50:25

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