RO 2433; GS-331007 MedChemExpress (MCE)

Product Name	2'-deoxy-2'-fluoro-2'-C-methyluridine
Synonyms	RO 2433 PSI-6206 2'-Deoxy-2-floro-2'Methyl-uridine 2'-deoxy-2'-fluoro-2'-C-methyluridine 2'-Deoxy-2'-Fluoro-2'-C-Methyl Uridine (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Uridine Synonyms RO 2433 PSI-6206 2'-Deoxy-2-floro-2'Methyl-uridine 2'-deoxy-2'-fluoro-2'-C-methyluridine 2'-Deoxy-2'-Fluoro-2'-C-Methyl Uridine (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Uridine Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
CAS	863329-66-2
EINECS	810-481-6
Chemical Formula	C10H13FN2O5
Molecular Weight	260.22
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	PSI-6206 PSI-6206 MedChemExpress (MCE) HY-15236 863329-66-2 RO 2433 Descriptions PSI-6206 PSI-6206 MedChemExpress (MCE) HY-15236 863329-66-2 RO 2433 GS-331007 99.89% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM. PSI-6206 (RO 2433) is tested for anti-HCV activity in both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. PSI-6206 demonstrates no activity or cytoxicity in any assay[1]. The formation of the 5′-triphosphate (TP) of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) increases with time and reached steady state levels at 48 h. RO2433-TP also inhibits RNA synthesis by the native HCV replicase isolated from HCV replicon cells and the recombinant HCV polymerase NS5B[2]. PSI-6206 (RO2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase[3]. EC90：>100 μM (HCV replicon)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25 48(17):5504-8. [Content Brief] [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12 282(41):29 [Content Brief] [3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4 74(17):6819-24. [Content Brief]
Supplier Website	https://www.medchemexpress.com/PSI-6206.html
Last Update	2025-05-21 16:50:25

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