N-0923; (-)-N 0437 MedChemExpress (MCE)

Product Name	Rotigotine
Synonyms	Neupro N 0923 SPM 962 Rotigotine (S)-2-[Propyl[2-(2-thienyl)ethyl]amino]tetralin-5-ol [S,(-)]-2-[Propyl[2-(2-thienyl)ethyl]amino]tetralin-5-ol ()-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-napht hol Synonyms Neupro N 0923 SPM 962 Rotigotine (S)-2-[Propyl[2-(2-thienyl)ethyl]amino]tetralin-5-ol [S,(-)]-2-[Propyl[2-(2-thienyl)ethyl]amino]tetralin-5-ol ()-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-napht hol (-)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol (6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol [2S,(-)]-N-Propyl-N-[2-(2-thienyl)ethyl]-5-hydroxy-1,2,3,4-tetrahydro-2β-naphthalenamine
CAS	99755-59-6
EINECS
Chemical Formula	C19H25NOS
Molecular Weight	315.47
inchi	InChI=1/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Rotigotine Rotigotine MedChemExpress (MCE) HY-75502 99755-59-6 N-0923 Descriptions Rotigotine Rotigotine MedChemExpress (MCE) HY-75502 99755-59-6 N-0923 (-)-N 0437 99.99% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research. Rotigotine (0.01-10 μM) slightly protects dopaminergic neurons against MPP+ toxicity dopamine, protects dopaminergic neurons against rotenone-induced cell death and significantly inhibits ROS production by rotenone[2]. Rotigotine (0.1-5 mg/kg i.h. for 14 days male Sprague–Dawley rats) has antidepressant effect[3]. D3 Receptor 0.71 nM (Ki) D2 Receptor 4-15 nM (Ki) D5 Receptor 4-15 nM (Ki) D4 Receptor 4-15 nM (Ki) D1 Receptor 83 nM (Ki) 5-HT1A Receptor 30 nM (Ki) 5-HT7 Receptor 86 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Wood M, et, al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb 172(4):1124-35. [Content Brief] [2]. Radad K, et, al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP⁺ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014 52(2):179-86. [Content Brief] [3]. Bertaina-Anglade V, et, al. Antidepressant properties of rotigotine in experimental models of depression. Eur J Pharmacol. 2006 Oct 24 548(1-3):106-14. [Content Brief] [4]. Scheller D, et, al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan 379(1):73-86. [Content Brief]
Supplier Website	https://www.medchemexpress.com/rotigotine.html
Last Update	2025-05-21 16:50:25

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