BI 6727 MedChemExpress (MCE)

Product Name	Volasertib (BI 6727)
Synonyms	CS-552 BI-6727 BI 6727 CS-1612 BI6727 BI-6727 Volasertib Synonyms CS-552 BI-6727 BI 6727 CS-1612 BI6727 BI-6727 Volasertib Volasertib (BI 6727) N-(Trans-4-(4-(cyclopropylMethyl)piperazin-1-yl)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-Methyl-6-oxo-5,6,7 N-[trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxybenzamide Benzamide, N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-
CAS	755038-65-4
EINECS	813-258-1
Chemical Formula	C34H50N8O3
Molecular Weight	618.81
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Volasertib Volasertib MedChemExpress (MCE) HY-12137 755038-65-4 BI 6727 99.87% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Volasertib Volasertib MedChemExpress (MCE) HY-12137 755038-65-4 BI 6727 99.87% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis. Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models. Volasertib (BI 6727 0.01-10000 nM 72 hours) has EC50 values of 11 to 37 nmol/L in multiple cell lines[1]. Volasertib (10-1000 nM 24 hours) results accumulation of cells with 4N DNA content, indicative of a cell cycle block in G2-M phase[1]. Volasertib (100 nM 24-72 hours) induces cell apoptosis at 48 hours[1]. Volasertib (BI 6727 A total weekly dose of 50 mg/kg Oral once a week, twice a week, or daily for 40 days) shows comparable efficacy in human colon carcinoma xenograft models[1]. Volasertib (15, 20, or 25 mg/kg/day i.v. 2 consecutive days per week for 40 days) leads to significant tumor growth delay and even tumor regression in human colon carcinoma xenograft models [1]. Volasertib (70 mg/kg given once weekly or 10 mg/kg daily oral) significantly delays tumor growth in a non-small cell lung carcinoma xenograft model derived from NCI-H460 cells[1]. Volasertib (a single dose of 40 mg/kg iv) causes a significant (13-fold) increase in mitotic cells in HCT 116 tumor-bearing nude mice[1]. Volasertib has high volume of distribution and a long terminal half-life in mice (Vss=7.6 L/kg, t1/2=46 h) and rats (Vss=22 L/kg, t1/2=54 h)[1]. PLK1 0.87 nM (IC50) PLK2 5 nM (IC50) PLK3 56 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Xie FF, et al. Volasertib suppresses tumor growth in cervical cancer. Am J Cancer Res. 2015 Nov 15 5(12):3548-59. [Content Brief] [2]. Rudolph D, et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity.Clin Cancer Res. 2009 May 1 15(9):3094-102. Epub [Content Brief]
Supplier Website	https://www.medchemexpress.com/Volasertib.html
Last Update	2025-04-01 14:45:47

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