Sirolimus (GMP Like); AY-22989 (GMP Like) MedChemExpress (MCE)

Product Name	Sirolimus
Synonyms	RPM RAPA AY 22989 RAPAMUNE RAPAMYCIN Sirolimus Rapamycin Synonyms RPM RAPA AY 22989 RAPAMUNE RAPAMYCIN Sirolimus Rapamycin Rapammune NSC-226080 (-)-Rapamycin Antibiotic AY 22989 RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS 23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE (3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a- Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-imethoxy- 6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3RS1R,3S,4S)),6S,7E,9S,10S,12S,14R,15E,17E,19E,21R,23R,26S,27S,34aR*))-
CAS	53123-88-9
EINECS	610-965-5
Chemical Formula	C51H79NO13
Molecular Weight	914.19
inchi	InChI=1/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12-,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38?,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
Package	10 mg;50 mg
Price	Email to quote
Descriptions	Rapamycin (GMP Like) Rapamycin (GMP Like) MedChemExpress (MCE) HY-10219GL 53123-88-9 Sirolimus (GMP Like) Descriptions Rapamycin (GMP Like) Rapamycin (GMP Like) MedChemExpress (MCE) HY-10219GL 53123-88-9 Sirolimus (GMP Like) AY-22989 (GMP Like) 98.8% 4°C, protect from light Room temperature in continental US may vary elsewhere. Rapamycin (Sirolimus) GMP Like is Rapamycin (HY-10219) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin is a potent and specific mTOR inhibitor. Rapamycin GMP Like (1 nM 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts[1]. Rapamycin GMP Like (1 nM 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs)[1]. Rapamycin GMP Like (20 nM 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation[2]. Rapamycin GMP Like induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells[3]. \| \| \| \| \| \| \| \| \| \| [1]. Lee KW, et al. Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. Stem Cells Dev. 2010 Apr 19(4):557-68. [Content Brief] [Content Brief] [2]. Martin KA, et al. Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling. J Biol Chem. 2007 Dec 7 282(49):36112-20. [Content Brief] [Content Brief] [3]. Ogawa T, et al. Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells. Biochem Biophys Res Commun. 1998 Aug 10 249(1):226-30. [Content Brief] [Content Brief]
Supplier Website	https://www.medchemexpress.com/rapamycin-gmp-like.html
Last Update	2025-05-21 16:50:25

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