SOS1 agonist-1 MedChemExpress (MCE)

Product Name	2,6-Diazaspiro[3.3]heptane-2-carboxylic acid, 6-[4-bromo-6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl]-, 1,1-dimethylethyl ester
Synonyms	2,6-Diazaspiro[3.3]heptane-2-carboxylic acid, 6-[4-bromo-6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl]-, 1,1-dimethylethyl ester tert-butyl 6-(4-bromo-6-chloro-1-(4-fluoro-3,5-dimethylbenzyl)-1H-benzo[d]imidazol-2-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate
CAS	2245237-61-8
EINECS
Chemical Formula	C26H29BrClFN4O2
Molecular Weight	563.89
inchi
Package	10 mM * 1 mL;5 mg;10 mg
Price	Email to quote
Descriptions	SOS1 agonist-1 SOS1 agonist-1 MedChemExpress (MCE) HY-153606 2245237-61-8 97.24% -20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions SOS1 agonist-1 SOS1 agonist-1 MedChemExpress (MCE) HY-153606 2245237-61-8 97.24% -20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. SOS1 agonist-1 (compound 79) is an agonist for the Son of sevenless homologue SOS1. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP to GTP on RAS and regulates RAS activation. SOS1 agonists increase nucleotide exchange on RAS, enhance cellular RAS-GTP levels, and trigger biphasic signaling changes in ERK1/2 phosphorylation. Play an anti-cancer role[1]. Son of sevenless homologue 1 (SOS1)[1] Molecular Weight 563.89 \| \| \| \| \| \| \| \| \| \| [1]. Hodges TR, Abbott JR, Little AJ, Sarkar D, Salovich JM, Howes JE, Akan DT, Sai J, Arnold AL, Browning C, Burns MC, Sobolik T, Sun Q, Beesetty Y, Coker JA, Scharn D, Stadtmueller H, Rossanese OW, Phan J, Waterson AG, McConnell DB, Fesik SW. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11 61(19):8875-8894. [Content Brief]
Supplier Website	https://www.medchemexpress.com/sos1-agonist-1.html
Last Update	2025-05-21 16:50:25

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