MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP) MedChemExpress (MCE)

Product Name	Monomethylauristatin E
Synonyms	MMAE Vedotin HM-297C-22 Monomethylauristatin E MonoMethyl auristatin E MonoMethyl auristatin E(MMAE, vedotin) (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxohe Synonyms MMAE Vedotin HM-297C-22 Monomethylauristatin E MonoMethyl auristatin E MonoMethyl auristatin E(MMAE, vedotin) (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxohe N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide Monomethyl
CAS	474645-27-7
EINECS
Chemical Formula	C39H67N5O7
Molecular Weight	717.98
inchi
Package	10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Monomethyl auristatin E Monomethyl auristatin E MedChemExpress (MCE) HY-15162G 474645-27-7 MMAE Descriptions Monomethyl auristatin E Monomethyl auristatin E MedChemExpress (MCE) HY-15162G 474645-27-7 MMAE SGD-1010 Vedotin -20°C, protect from light Shipping with dry ice. Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor. Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells[1]. Monomethyl auristatin E (MMAE) sensitizes colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. Radiosensitization is evidenced by decreased clonogenic survival and increased DNA double strand breaks in irradiated cells[2]. Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolongs tumor regression in xenograft models[2]. \| \| \| \| \| \| \| \| \| \| [1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. [Content Brief] [2]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1 75(7):1376-87. [Content Brief]
Supplier Website	https://www.medchemexpress.com/monomethyl-auristatin-e-gmp.html
Last Update	2025-05-21 16:50:25

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