KX-02 MedChemExpress (MCE)

Product Name	KX-02 KX-2-361 KX-2361
Synonyms	KX-02);KX2-361(KX-2361;KX-02 KX-2-361 KX-2361;2-Pyridineacetamide, N-[(3-fluorophenyl)methyl]-5-[4-(4-morpholinyl)phenyl]-
CAS	897016-26-1
EINECS
Chemical Formula	C24H24FN3O2
Molecular Weight	405.46
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	KX2-361 KX2-361 MedChemExpress (MCE) HY-111187 897016-26-1 KX-02 99.55% 4°C, protect from light In solvent : -80°C, 6 months Descriptions KX2-361 KX2-361 MedChemExpress (MCE) HY-111187 897016-26-1 KX-02 99.55% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell. KX2-361 (0-200 nM, 24-72 h) reduces autophosphorylation of Src in GL261 cells[1]. KX2-361 (0-270 nM) promotes cell cycle arrest at the G2/M phase in U87 cells. Note the dose dependent effect and virtual complete arrest at 270 nM[1]. KX2-361 (0-800 nM) induces apoptosis of U87, GL261 and T98G cell lines[1]. KX2-361 (5 µM) inhibits the in vitro assembly of tubulin polymers[1]. KX2‑361 significantly delays progression of orthotopic GL261 brain tumors and produces long‑term survival[1]. KX2-361 demonstrates appreciable brain penetration when dosed orally to mice (20 mg/kg), with a brain Cmax of 4025±319 ng/g observed 15 min post-dosing and an overall exposure (AUClast) of 5044±355 h ng/g[1]. \| \| \| \| \| \| \| \| \| \| [1]. Ciesielski MJ, et al. KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. J Neurooncol. 2018 Dec 140(3):519-527. [Content Brief]
Supplier Website	https://www.medchemexpress.com/kx2-361.html
Last Update	2025-05-21 16:50:25

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