MyD88-IN-1 MedChemExpress (MCE)

Product Name	MyD88-IN-1
Synonyms	MyD88-IN-1
CAS	2911609-80-6
EINECS
Chemical Formula	C23H24N6O7S
Molecular Weight	528.54
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	MyD88-IN-1 MyD88-IN-1 MedChemExpress (MCE) HY-149992 2911609-80-6 99.95% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions MyD88-IN-1 MyD88-IN-1 MedChemExpress (MCE) HY-149992 2911609-80-6 99.95% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. MyD88-IN-1 (Compound c17) is an orally active MyD88 inhibitor. MyD88-IN-1 inhibits the interaction of TLR4 and MyD88 and suppressed the NF-κB pathway. MyD88-IN-1 can be used in research of cancer and inflammatory. MyD88-IN-1 (10 μM, 24 h) exhibits significant anti-inflammatory effects in LPS (HY-D1056)-induced J774A.1 macrophages[1]. MyD88-IN-1 (40 or 80 μM, 2 h) restores IκB-α expression and inhibits p65 phosphorylation and nuclear translocation, indicating that it exerts anti-inflammatory effects by suppressing the NF-κB signaling pathway[1]. MyD88-IN-1 (40 or 80 μM, 2 h) exerts its anti-inflammatory activity in J774A.1 macrophages by inhibiting TLR4-MyD88 interaction[1]. MyD88-IN-1 (20 mg/kg, p.o., single dose) exhibits significant anti-inflammatory effects and alleviates lung tissue injury in the LPS (HY-D1056)-induced ALI mouse model[1]. \| \| \| \| \| \| \| \| \| \| [1]. Chen P, et, al. Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen. J Med Chem. 2023 May 25 66(10):6938-6958. [Content Brief]
Supplier Website	https://www.medchemexpress.com/myd88-in-1.html
Last Update	2025-05-21 16:50:25

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