Name | Glycerin |
Synonyms | Glyceol Glycerol Glycerin Emery 912 Glycerine D-glycerol glyceritol L-glycerol Propanetriol Glycerin USP Glycerin mist glycyl alcohol glycerin(mist) trihydroxypropane glycerin,anhydrous 1,2,3-propanetriol glycerin,synthetic Glycerin, anhydrous Polyhydric alcohols propane-1,1,1-triol Glycerin, synthetic 1,2,3-Trihydroxypropane |
CAS | 56-81-5 |
EINECS | 200-289-5 |
InChI | InChI=1/C3H8O3/c1-2-3(4,5)6/h4-6H,2H2,1H3 |
InChIKey | PEDCQBHIVMGVHV-UHFFFAOYSA-N |
Molecular Formula | C3H8O3 |
Molar Mass | 92.09 |
Density | 1.25 g/mL(lit.) |
Melting Point | 20°C(lit.) |
Boling Point | 290 °C |
Specific Rotation(α) | n20/D 1.474 (lit.) |
Flash Point | 320°F |
JECFA Number | 909 |
Water Solubility | >500 g/L (20 ºC) |
Solubility | It is miscible in alcohol, miscible with water, insoluble in chloroform, ether, and oil. |
Vapor Presure | <1 mm Hg ( 20 °C) |
Vapor Density | 3.1 (vs air) |
Appearance | Clear Viscous Liquid |
Specific Gravity | 1.265 (15/15℃)1.262 |
Color | APHA: ≤10 |
Odor | Odorless. |
Exposure Limit | OSHA: TWA 15 mg/m3; TWA 5 mg/m3 |
Maximum wavelength(λmax) | ['λ: 260 nm Amax: 0.05', , 'λ: 280 nm Amax: 0.04'] |
Merck | 14,4484 |
BRN | 635685 |
pKa | 14.15(at 25℃) |
PH | 5.5-8 (25℃, 5M in H2O) |
Storage Condition | Store at +5°C to +30°C. |
Stability | Stable. Incompatible with perchloric acid, lead oxide, acetic anhydride, nitrobenzene, chlorine, peroxides, strong acids, strong bases. Combustible. |
Sensitive | Hygroscopic |
Explosive Limit | 2.6-11.3%(V) |
Refractive Index | n20/D 1.474(lit.) |
MDL | MFCD00004722 |
Physical and Chemical Properties | Colorless, transparent, odorless, viscous liquid, sweet, with hygroscopicity. The solubility is miscible with water and ethanol, and the aqueous solution is neutral. Dissolve in 11 times of ethyl acetate, about 500 times of ether. Insoluble in benzene, chloroform, carbon tetrachloride, carbon disulfide, petroleum ether, oil. |
Use | Used as basic organic chemical raw materials, widely used in medicine, food, daily chemical, textile, paper, paint and other industries |
Risk Codes | R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S24/25 - Avoid contact with skin and eyes. S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | UN 1282 3/PG 2 |
WGK Germany | 1 |
RTECS | MA8050000 |
FLUKA BRAND F CODES | 3 |
TSCA | Yes |
HS Code | 29054500 |
Toxicity | LD50 in rats (ml/kg): >20 orally; 4.4 i.v. (Bartsch) |
a colorless, odorless, viscous liquid. Sweet. Strong hygroscopicity. Can absorb hydrogen sulfide, hydrogen cyanide, sulfur dioxide. Miscible with water and ethanol, 1 part of the product can be dissolved in 11 ethyl acetate, about 500 parts of ether, insoluble in benzene, carbon disulfide, chloroform, carbon tetrachloride, petroleum ether, oils. It is easy to be dehydrated and lose water to produce diglycerols and polyglycerols. The oxidation generates glyceraldehyde and glyceric acid, etc. Solidification at 0 °c, the formation of a flash of orthorhombic crystals. At temperatures around 150 °c, polymerization occurs. With anhydrous acetic anhydride, potassium permanganate, strong acid, corrosion agent, fatty amine, isocyanate, oxidant is not compatible.
Industrial glycerol diluted with an appropriate amount of water, through ion exchange, and vacuum distillation dehydration, plus activated carbon adsorption decolorization, filtration to remove activated carbon is pure.
This product is 1,2, 3-propanetriol. The content of C3H80 3 shall not be less than 95.0% calculated as anhydrous.
The relative density of this product (General rule 0601) in 2 5 t: when not less than 1. 257.
The refractive index of this product (General 0622) should be 1.470~1.475.
gas chromatography stationary liquid. The boron complexing agent was measured. Used as a solvent, lubricant, cosmetic formulation and pharmaceutical industry.
The infrared absorption spectrum of this product should be consistent with the spectrum of the control (Spectrum set 7 7 figure).
rat oral LD50: 20mL/kg * intravenous LDso:4.4mL/kg. Stored in a cool, dry place.
take 25.0g of this product, dilute to 50ml with water, mix well, add phenolphthalein indicator solution 0.5m l, the solution should be colorless, add 0. lm o l/L sodium hydroxide solution 0 .2 m l, the solution should be pink.
take 50ml of this product, put it in 50ml Nessler's colorimetric tube, and compare it with the control solution (take 0. 2 m l potassium dichromate solution for color comparison, and dilute it to 50ml).
take this product & 0g, check according to law (General rule 0801), compared with the standard sodium chloride solution 7. 5m made of the control solution, not more concentrated (0. 0015%).
Take 10g of this product and check it according to law (General rule 0802). Compared with the control solution made of 2. Oral standard potassium sulfate solution, it should not be more concentrated (0.002%).
take about l g of this product, put it in a 50ml measuring flask, add 25ml of water to dissolve, and add the newly prepared 10% methyl benzothiazolone hydrochloride hydrazone solution (0. 0 2M o l/L sodium hydroxide solution to adjust the p H value to 4. 0. Add 5ml of freshly prepared 0 .5% ferric chloride solution, shake well, stand still for 5 minutes, dilute to the scale with methanol, and shake well. According to UV-visible spectrophotometry (General rule 0401), determine the absorbance at the wavelength of 655nm, and the absorbance of the test solution shall not be greater than that of the reference solution [formaldehyde (CH20) per lm l] 5 .0mg] 2. The absorbance of l 0m after treatment with the same method.
Take 5.0g of this product, add 5ml of water, mix well, add dilute sulfuric acid lm l, put on a water bath and heat for 5 minutes, add 2xnol/L sodium hydroxide solution without carbonate 3 m l, copper sulfate test solution lm l was added dropwise, mixed well, should be blue clear solution, continue to heat on the water bath for 5 minutes, the solution should remain blue, no precipitation.
Take 40g of this product, add new boiling cold water 40ml, and then add sodium hydroxide titration solution (0. ltn o l/L ) 10ml, shake well, boil for 5 minutes, let cool, add phenolphthalein indicator liquid several drops, with hydrochloric acid titration liquid (0. lm o l/L) titration until the red turtle disappears, and the results of the titration are corrected with a blank test. Consumption of sodium hydroxide titration solution (0. lm o l/L) should not exceed 4.0 ml.
take 4.0g of this product, and add 5ml of human sulfuric acid Dropwise under shaking. During the process, the temperature should not exceed 20°C. After standing for 1 hour, if the color is developed, with the same volume of control solution (take the gasification cobalt solution for colorimetric 0.2ml, colorimetric potassium dichromate solution 1 .6M l with water 8 .2M l made) comparison, not deeper.
take about 10g of this product, precision weighing, 25ml measuring flask, precision plus internal standard solution (containing 0 .5M g of N-hexanol in methanol) 5m U was dissolved in methanol and diluted to the scale as a test solution. Take the appropriate amount of diethylene glycol, ethylene glycol and 1, 2-propanediol, weigh them precisely, dissolve them with methanol and dilute them to make the contents of diglycol, ethylene glycol and 1 in each l m l, 2-propanediol 0.5 m g of the solution, the precision of 5ml, put the 25ml measuring flask, precision plus the internal standard solution 5 m l, diluted to the scale with fermentation, as a reference solution. Separately take the appropriate amount of diethylene glycol, ethylene glycol, 1, 2-propanediol, n-hexanol and glycerin, weigh it precisely, dissolve and dilute it with methanol to make 400mg of glycerin per lm l, diethylene glycol, ethylene glycol, 1, 2-propanediol, n-hexanol 0. lm g solution, as the system suitability solution, according to Gas chromatography (General 0521), with 6% cyanopropylphenyl-94% dimethyl polysiloxane as the stationary liquid (or polar similar stationary liquid) capillary column, program l-f, starting at 100TTC, for 4 minutes, ramp up to 1 20°C at a rate of 50 t per minute, for 10 minutes, then the temperature is raised to 220°C at a rate of 50°C per minute for 20 minutes; The temperature of the injection port is 200°C, and the temperature of the detector is 250°C, the chromatogram was recorded at least twice the retention time of the main peak. Take the system applicability test solution 1M1, inject into the gas chromatograph, record the chromatogram, and the separation degree between the chromatographic peaks of each component shall meet the requirements. The relative standard deviation of the ratio of the peak area of diethylene glycol and ethylene glycol to the peak area of the internal standard shall not be more than 5% after repeated injection of the reference solution. Accurately take the test solution and the reference solution I # , inject human gas chromatography, record the chromatogram, according to the internal standard method to calculate the peak area, the test product containing diethylene glycol, ethylene glycol shall not exceed 0.025%; containing 1,2-propylene glycol shall not exceed 0.1%; If there are other impurity peaks, the internal standard peak is subtracted and calculated by area normalization method, the single unknown impurity shall not exceed 0.1%; The total amount of impurities (including diethylene glycol, ethylene glycol and 1, 2-propanediol) should not exceed 1.0%.
take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed.
Take 20. 0g of this product, heat to spontaneous combustion, stop heating, after burning is completed, cool, check according to law (General rule 0841), residue shall not pass 2mg.
take 4.0g of this product, add 5ml of 10% potassium hydroxide solution, mix well, place at 60°C for 5 minutes, and ammonia odor will not occur.
take this product 10. 0G, check according to law (General rule 0807) and standard iron solution 2. 0M l made of control liquid comparison, not deeper (0.0002%).
take this product 5.0g, inspection according to law (General 0821), containing heavy metals shall not exceed 2 parts per million.
take 6.65g of this product, add 23ml of water and 5m l of hydrochloric acid, and check according to law (General rule 0822, the first law), shall comply with the provisions (0.000 03%).
take this product about O. lg, precision weighing, add water 45ml, mix well, Precision Add 2. 14% Sodium periodate solution 2 5 m l, shake well, after 15 minutes in the dark, add 50% (g /m l) ethylene glycol solution 1 0 m l, shake well, place it in the dark for 20 minutes, add 0.5 of phenolphthalein indicator solution, and use sodium hydroxide titration solution (0.1 M o l/L) titration to red, no fading in 30 seconds, and the results of the titration were corrected with a blank test. Each lm l sodium hydroxide titration solution (0. lm o l/ IJ is equivalent to 9.21 mg of C3 H80 3.
pharmaceutical excipients, solvents and suspending agents.
sealed and stored in a dry place.
This product can form a complex with boric acid, which will decompose and release toxic acrolein. It may be subject to explosion with strong oxidant, and will turn black by light or contact with basic bismuth nitrate and oxidant.
take the glycerin, heat it to 120°C in a steam sandwich pan, add the dried sodium stearate, stir constantly, dissolve it, and keep it at 85-95°C until the solution is clear, filtering, casting, cooling into a walk, demoulding, ready to get.
This product is colorless or almost colorless transparent or translucent plug.
In addition to not checking the melting time limit, the other items should be consistent with the relevant provisions under The suppository (General 0107).
lubricating laxative.
sealed and stored at 30°C or less.
This product is a sterile aqueous solution containing glycerol, fructose and sodium chloride. Glycerol (C3H8O3) shall be 90.0% to 110.0% of label amount and fructose (C6H1206) and sodium chloride (NaCI) shall be 93.0% to 107.0% of label amount.
glycerol 100g
Fructose 50g
Sodium chloride 9g
Appropriate amount of water for injection
Full Volume 1000ml
This product is a clear colorless liquid.
dehydration drugs.
(l)250ml (2) 500ml
sealed storage.