EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Overview | Tyramine is one of the top ten veterinary antibiotics, its antibacterial spectrum is similar to macrolide antibiotics, mainly against gram-positive bacteria, it has a strong inhibitory effect on Staphylococcus aureus, Streptococcus, Mycoplasma, porcine Actinobacillus pleuropneumoniae, swine Treponema dysentery, and the effect on Mycoplasma is stronger than that of macrolides. |
Use | the absorption of the drug in the animal body is rapid, the blood concentration is high, the body is widely distributed, and the residue is low. It is mainly used for the prevention and treatment of chicken chronic respiratory disease, swine Mycoplasma Pneumonias, Actinomyces pleuropneumonia and dysentery, etc. When used in low doses, it can promote animal growth and improve feed utilization. The drug has been widely used in the world, and has been recommended as the first choice for the control of Mycoplasma infection, and the market demand is large. |
antimicrobial spectrum | against Mycoplasma, Actinobacillus pleuropneumoniae, shigellosis, it has a strong inhibitory effect on Mycoplasma, which is better than that of macrolides. |
Application | is mainly used for the treatment of various bacterial respiratory diseases, such as asthma, Transmissibility pleural pneumonia; also commonly used in the treatment of certain digestive tract infections, such as swine dysentery, ileitis and so on. Among them, the effect of Mycoplasma infection and Ileitis is better than that of macrolides. Compatibility of tyramine: Prohibited with Polyether ion antibiotics (such as monensin, salinomycin, etc.). |
incompatibility | 1) antagonism, because of the similar antibacterial mechanism between lincoamine antibiotics, there is competitive antagonism, so it can not be used at the same time. In addition, tiamulin can not be used together with Polyether antibiotics (salinomycin, moxinmycin, etc.), because the combined use can lead to animal movement disorders, muscle degeneration and other diseases, and even lead to death in severe cases. 2) Synergy: tyramine with tetracyclines (doxycycline, oxytetracycline, chlortetracycline), polypeptides (colistin sulfate), beta-lactams (amoxicillin), aminoglycosides (gentamicin, kanamycin), sulfa antibiotics can be used in combination. Among them, compared with the classic group, the Group of the drug, the drug, the drug, the drug, and the doxycycline. |
biological activity | Tiamulin is a semi-synthetic truncated quinolone antibiotic, which binds to the ribosomal peptidyl transferase center, inhibition of protein synthesis. |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |