tert-Butyl (also known as tert-butyl 4-amino-4-methylpiperidine-1-carboxylate) is an organic compound whose chemical structure contains a tert-butyl protecting group (Boc), an amino group and a methyl oxycarboxylate.
Nature:
-Appearance: White solid
-Molecular formula: C12H23N2O2
-Molecular Weight: 225.33
-Melting Point: 48-52°C
-Boiling point: 320-322°C
-Solubility: Soluble in organic solvents such as ethers, ketones and dichloromethane
Use:
tert-Butyl is an important intermediate in organic synthesis and is often used in the field of pharmaceutical synthesis. It can be used in the synthesis of various pharmaceutical compounds, such as anti-tumor agents, antiviral drugs, cholinergic agonists and anti-anxiety drugs.
Preparation Method:
tert-Butyl can be prepared by the following steps:
1. react 1-oxazolyl -4-amino-4-methyl piperidine with tert-butyl dicarboxylic anhydride to generate tert-Butyl Boc-protected anhydride derivative.
2. Then it reacts with methanol and silver carbonate to remove the oxazole protecting group to generate tert-Butyl.
Safety Information:
tert-Butyl is less toxic when handled correctly. However, it is a flammable solid and contact with ignition sources should be avoided. Wear protective glasses and gloves when using, and maintain good ventilation. When handling or handling this compound, avoid inhaling its dust or contact with skin and eyes. Before use, read and understand the safety data sheet (MSDS) of the chemical substance and follow the relevant safety procedures.