tert-Butyl 4-(2-oxoethyl)
N-Boc-4-Piperidineacetaldehyde
CAS: 142374-19-4
Molecular Formula: C12H21NO3
tert-Butyl 4-(2-oxoethyl) - Names and Identifiers
tert-Butyl 4-(2-oxoethyl) - Physico-chemical Properties
| Molecular Formula | C12H21NO3 |
| Molar Mass | 227.3 |
| Density | 1.035±0.06 g/cm3(Predicted) |
| Melting Point | 38-42 °C |
| Boling Point | 318.1±15.0 °C(Predicted) |
| Flash Point | >110℃ |
| pKa | -1.62±0.40(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Use | This product is for scientific research only and shall not be used for other purposes. |
tert-Butyl 4-(2-oxoethyl) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
tert-Butyl 4-(2-oxoethyl) - Reference Information
| Use | 4-(2-oxoethyl) piperidin-1-carboxylic acid tert-butyl ester is a carboxylate derivative and can be used as an intermediate in organic synthesis. |
| prepare | a, add compound 1(66g, 0.512 mol) and triethylamine (224mL) to chloroform (1L), then add Boc2O(117g, 0.537 mol) to react at 0 ℃. The mixture should be stirred at room temperature for 1 hour. TLC (dichloromethane/methanol volume ratio = 10/1) showed the end of the reaction. The reacted mixture was washed with ammonium chloride (500mL x 2), then added with sodium sulfate, dried, filtered and spirled to obtain compound 2(120g) in 100% yield. B. oxalyl chloride (50g, 0.394 mol) was added to dichloromethane (1L), dimethyl sulfoxide (45.9 mL, 0.6575 mol) was slowly added at -60 ℃, and stirred for 30 minutes. Dissolve compound 2(120g, 100%) in dichloromethane (500mL) at -60 ℃, and then slowly pour it into the above reaction. After adding, the mixture needs to be stirred at -60°C for 1 hour. TLC (petroleum ether/ethyl acetate volume ratio = 2/1) showed the end of the reaction. Triethylamine (183mL, 1.315mol) was added at minus 60 ℃ and stirred for 30 minutes. The reaction solution was raised to room temperature, and then water (1L) was added to separate the organic phase. The aqueous phase was extracted with ethyl acetate (500 mL x 3). The combined organic phase was washed twice with ammonium chloride (500mL), and then dried with sodium sulfate to obtain a 100% yield of light yellow oily compound 3(60g). |
Last Update：2024-04-09 21:11:58
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View History
tert-Butyl 4-(2-oxoethyl)
1-Butanol, 4-(phenylamino)-
Ethyl 4-(4-fluorophenyl)-2-methylquinoline-3-carboxylate
N-Benzylideneglycine tert-butyl ester
390815-44-8
1-Butanol, 4-(phenylamino)-
Ethyl 4-(4-fluorophenyl)-2-methylquinoline-3-carboxylate
N-Benzylideneglycine tert-butyl ester
390815-44-8