Name | synephrine |
Synonyms | oxedrine SYNEPHRINE synephrine Synephrine SYNEPHERINE AKOS NCG1-0008 2-[1-hydroxy-2-(methylamino)ethyl]phenol 4-(1-hydroxy-2-(methylamino)ethyl)phenol 1-[4-HYDROXYPHENYL]-2-METHYLAMINOETHANOL 4-Hydroxy-alpha-(methylaminomethyl)benzyl 4-[(1S)-1-hydroxy-2-(methylamino)ethyl]phenol 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol 4-hydroxy-alpha-(methylaminomethyl)benzyl alcohol |
CAS | 94-07-5 575-81-5 |
EINECS | 202-300-9 |
InChI | InChI=1/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1 |
Molecular Formula | C9H13NO2 |
Molar Mass | 167.21 |
Density | 1.1222 (rough estimate) |
Melting Point | 187°C (dec.)(lit.) |
Boling Point | 295.79°C (rough estimate) |
Flash Point | 163.4°C |
Solubility | Easily soluble in water, hardly soluble in ether, |
Vapor Presure | 3.18E-05mmHg at 25°C |
Appearance | Colorless crystal (ethanol-ether) |
Color | White to Off-White |
Merck | 14,9012 |
pKa | pKa 9.60±0.02(H2Ot = 25.0±0.5I = 0.01)(Approximate) |
Storage Condition | 2-8°C |
Stability | Hygroscopic |
Refractive Index | 1.4680 (estimate) |
MDL | MFCD00002370 |
Physical and Chemical Properties | Hydrochloride, colorless crystal (ethanol-ether), melting point: 166 ℃-167 ℃,[α]27D-52. (C = 7.6 mg/ml, anhydrous methanol). In strong acid, strong base ion exchange resin chromatography separation is prone to racemization. Crystallization, melting point: 184 ℃-185 ℃; Hydrochloride crystallization, melting point: 151 ℃-152 ℃, easily soluble in water; Btartrate, 188 ℃-189 ℃ (partial decomposition), easily soluble in water, hardly soluble in ether, almost insoluble in chloroform and ether. |
Use | Used as a vasopressor |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | DO7350000 |
HS Code | 29225090 |
Reference Show more | 1. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 2. [IF=4.411] Liuyi Yu et al."Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method."Molecules. 2020 Jan;25(2):357 3. [IF=4.411] Simona S. Ghanem et al."Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity."Molecules. 2021 Jan;26(12):3736 |