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rac-Vigabatrin Hydrochloride

rac-Vigabatrin Hydrochloride

CAS: 1391054-02-6

Molecular Formula: C6H12ClNO2

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rac-Vigabatrin Hydrochloride - Names and Identifiers

Name rac-Vigabatrin Hydrochloride
Synonyms Vigabatrin HCL
SABRIL HYDROCHLORIDE
Vigabatrin (Hydrochloride)
γ-Vinyl-GABA hydrochloride
Γ-VINYL-GABA HYDROCHLORIDE
rac-Vigabatrin Hydrochloride
4-aminohex-5-enoic acid hydrochloride
CAS 1391054-02-6

rac-Vigabatrin Hydrochloride - Physico-chemical Properties

Molecular FormulaC6H12ClNO2
Molar Mass165.61798
Storage Condition2-8℃
In vitro study A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin.
In vivo study Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models.

rac-Vigabatrin Hydrochloride - Preparation solution concentration reference

 1mg5mg10mg
1 mM6.038 ml30.19 ml60.379 ml
5 mM1.208 ml6.038 ml12.076 ml
10 mM0.604 ml3.019 ml6.038 ml
5 mM0.121 ml0.604 ml1.208 ml
Last Update:2024-01-02 23:10:35
rac-Vigabatrin Hydrochloride
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
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Shanghai Macklin Biochemical Co., Ltd
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Product Name: Vigabatrin Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 1391054-02-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: rac-Vigabatrin Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 1391054-02-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
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