Name | psoralen |
Synonyms | psoralen PSORALEN Furo(4',5',6,7)coumarin furo(2',3',7,6)coumarin Fructus Psoraleae extract 7H-furo[3,2-g]chromen-7-one Psoralea corylifolia Linn. Extract TGRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRY MJJNNNNNNN |
CAS | 66-97-7 |
EINECS | 200-639-7 |
InChI | InChI=1/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H |
InChIKey | ZCCUUQDIBDJBTK-UHFFFAOYSA-N |
Molecular Formula | C11H6O3 |
Molar Mass | 186.16 |
Density | 1.2477 (rough estimate) |
Melting Point | 160-162°C |
Boling Point | 280.64°C (rough estimate) |
Flash Point | 173.1°C |
Water Solubility | 65.16mg/L(25 ºC) |
Solubility | Soluble in ethanol, chloroform, slightly soluble in water, ether and petroleum ether. |
Vapor Presure | 1.91E-05mmHg at 25°C |
Appearance | Colorless needle crystal |
Color | White to Off-White |
Maximum wavelength(λmax) | ['328nm(EtOH)(lit.)'] |
Merck | 14,7928 |
BRN | 152784 |
Storage Condition | 2-8°C |
Sensitive | Sensitive to heat and light |
Refractive Index | 1.6310 (estimate) |
MDL | MFCD00010520 |
Physical and Chemical Properties | Psoralea corylifolia L. Fruit from legume Psoralea |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | LV0944000 |
FLUKA BRAND F CODES | 8-10 |
HS Code | 29339900 |
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Simultaneous determination of psoralen, isopsoralen, atractylenolide Ⅲ and isoimperatorin in Shenling Baizhu powder by UPLC [J]. Journal of Shenyang Pharmaceutical University 2018 35(07):568-573. 6. Zheng Nan, Guo Yihua, Liu Diao, et al. Study on fingerprint of different processed products of Psoralea corylifolia L. [J]. Liaoning Journal of Traditional Chinese Medicine, 2015(04):157-159. 7. Xiaofen Liu, Bing Lai, Bing song, Xiubi et al. Determination of three coumarins in radix glehniae from Fujian province by HPLC [J]. Modern distance education of traditional Chinese medicine in China, 18 Vol. 10, 2020. 8. Cong Jianmin, Chen Fengqing, Ye Junshuang, etc. Study on extraction technology and antibacterial activity of coumarin from Melilotus [J]. Natural product research and development, 2014, 026(004):588-593,596. 9. Huang Ting, Guo Yuhua, Ding Liyan, etc. Effect of Psoralea corylifolia L. Juice on anti-OP chemical composition [J]. 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Zhang, Yuzhu, et al. "Effects of psoralen on the pharmacokinetics of anastrozole in rats." Pharmaceutical biology 56.1 (2018): 433-439.https://doi.org/10.1080/13880209.2018.1501584 15. Chen, Xiumin, Yanfang Yang and Yingtao Zhang. "Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro." Febs Letters 587.18 (2013): 2930-2935.https://doi.org/10.1016/j.febslet.2013.07. 16. Yang, Yan-Fang, Lei Zhang, and Xiu-Wei Yang. "Distribution assessments of coumarins from Angelicae Pubescentis Radix in rat cerebrospinal fluid and brain by Liquid Chromatography Tandem Mass Spectrometry analysis ." Molecules 23.1 (2018): 225.https://doi.or 17. [IF=5.192] Lin Ji et al."Psoralen, a mechanism-based inactivator of CYP2B6."Chem-Biol Interact. 2015 Oct;240:346 18. [IF=4.411] Liang Yang et al."New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum."Molecules. 2016 Apr;21(4):468 19. 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[IF=2.675] Xiumin Chen et al."Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro."Febs Lett. 2013 Sep;587(18):2930-2935 24. [IF=6.576] Li Guijie et al."Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice."Front Nutr. 2021 Jun;0:329 25. [IF=4.36] Yang Zhao et al."Shashen-Maidong Decoction improved chronic intermittent hypoxia-induced cognitive impairment through regulating glutamatergic signaling pathway."J Ethnopharmacol. 2021 Jun;274:114040 26. [IF=4.162] Guijie Li et al."Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil."Drug Des Dev Ther. 2021; 15: 937-947 27. [IF=1.771] Lin Yongtao et al."Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874."Bmc Pharmacol Toxico. 2020 Dec;21(1):1-10 |