Name | niclosamide |
Synonyms | SR 73 Bayer 73 bayluscid Nc osamide niclosamide NICLOSAMID PESTANAL Bayer 25648,Bayluscide Niclosamide 1420-04-8, NICLOSAMID PESTANAL 250 MG 2,5-dichloro-4-nitrosalicylanilide 2',5-dichloro-4'-nitrosalicylanilide 5-chloro-2'-chloro-4'-nitrosalicylanilide 2',5-dichlor-4'-nitro-salizylsaeureanilid 5-chloro-n-(2-chloro-4-nitrophenyl)salicylamide 2-CHLORO-4-NITROHENYLAMIDE-6-CHLOROSALICYLIC ACID 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza 5-chloro-N-(2-chloro-5-nitrophenyl)-2-hydroxybenzamide 2-hydroxy-5-chloro-n-(2-chloro-4-nitrophenyl)benzamide 5-CHLORO-N-(2-CHLORO-5-NITROPHENYL)-2-HYDROXYBENZAMIDE 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 6-Benzylamino-2(R)-[[1-(hydroxymethyl)-propyl]amino-9-isopropylpurin] |
CAS | 50-65-7 |
EINECS | 200-056-8 |
InChI | InChI=1/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-6-8(17(20)21)2-3-10(11)15/h1-6,18H,(H,16,19) |
InChIKey | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
Molecular Formula | C13H8Cl2N2O4 |
Molar Mass | 327.12 |
Density | 1.6646 (rough estimate) |
Melting Point | 225-230° |
Boling Point | 424.5±45.0 °C(Predicted) |
Flash Point | 204.122°C |
Water Solubility | 13.32mg/L(25 ºC) |
Solubility | acetone: methanol: soluble50mg/mL (methanol:acetone (1:1)) |
Vapor Presure | 0mmHg at 25°C |
Appearance | Pale yellow solid |
Color | Yellow |
BRN | 2820605 |
pKa | 7.45±0.43(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
Refractive Index | 1.6200 (estimate) |
MDL | MFCD00057597 |
Physical and Chemical Properties | Yellowish white crystalline powder, odorless, tasteless. Melting point 225-230 °c. Insoluble in water, soluble in hot ethanol, chloroform, cyclohexanone, ether and sodium hydroxide solution. |
Use | Used as an anti-helminth drug |
Risk Codes | 50 - Very Toxic to aquatic organisms |
Safety Description | 29 - Do not empty into drains. |
UN IDs | UN 3077 9/PG 3 |
WGK Germany | 2 |
RTECS | VN8400000 |
HS Code | 29242990 |
Toxicity | LD50 oral in rat: 2500mg/kg |
yellow-white crystalline powder, odorless, tasteless. The melting point was 225-230 °c. Insoluble in water, soluble in hot ethanol, chloroform.
2 monochloro-4-nitroaniline and 5 monochlorosalicylic acid are dissolved in xylene (or chlorobenzene) in an equimolar ratio, and phosphorus trichloride (or phosphorus oxychloride) is slowly added under boiling, refluxed and cooled, the crystals were filtered off as Niclosamide.
The new anti-tapeworm drug has effect on a variety of Hook and non-hook tapeworm. Can be used to fight pigs and cattle and other animals in the body of the tapeworm, can also be used to kill the water snail, freshwater snails, the snail and snail eggs are effective.