Application | M-chloro-iodobenzene compounds have the characteristics of low environmental pollution, low price, good stability and transition metal, has been widely used in industrial chemistry, agricultural chemistry and pharmaceutical chemistry, as selective oxidants and green coupling reagents in a variety of oxidation reactions, rearrangement reactions, amination Reactions and catalytic reactions in place of transition metals play an important role. |
preparation method | The preparation steps of M-chloro-iodobenzene are as follows: 4-nitroaniline (2 mmol,0.276g), Silica sulfuric acid (1.35g), and NaNO2(4 mmol,0.256g) were ground in a mortar using a pestle for several minutes to provide a homogeneous mixture. A few drops of water were gradually added and the reaction mixture was ground for 20 minutes until gas evolution ceased. Next, KI(5 mmol,0.83g) was added to the diazonium salt and milling was continued for 10 min. The mixture was diluted with EtOAc(12 mL) and filtered after vigorous stirring. The residue was extracted with EtOAc(3 x 12 mL) and the combined organic layers were washed with 10% aq Na2SO3 solution and then dried over anhydrous Na2SO4. The solvent was evaporated in vacuo to give the target compound in 84% yield. Infrared (KBr):3058, 1595, 1562, 1450, 1400, 1325, 1160, 1112, 1060, 1005, 875, 770, 745, 670 cm-1.1H NMR (250 MHz,CDCl3) Δ = 7.95(s,1 H), 7.80(d,J = 7.9Hz,1 H). |