glycyrrhetinic acid hydrogen succinate
Carbenoxolone
CAS: 5697-56-3
Molecular Formula: C34H50O7
glycyrrhetinic acid hydrogen succinate - Names and Identifiers
glycyrrhetinic acid hydrogen succinate - Physico-chemical Properties
| Molecular Formula | C34H50O7 |
| Molar Mass | 570.76 |
| Density | 1.20 |
| Melting Point | 291-294 °C |
| Boling Point | 553.75°C (rough estimate) |
| Specific Rotation(α) | D20 +128° (chloroform) |
| Water Solubility | 6.621mg/L(24 ºC) |
| Solubility | Chloroform methanol mixture |
| Appearance | White crystalline powder |
| Color | Cream crystals |
| pKa | pKa 6.7 (Uncertain) |
| Storage Condition | -20°C Freezer |
| Refractive Index | 1.5820 (estimate) |
| MDL | MFCD00867458 |
glycyrrhetinic acid hydrogen succinate - Risk and Safety
| Toxicity | LD50 orl-rat: 2450 mg/kg OYYAA2 19,323,80 |
glycyrrhetinic acid hydrogen succinate - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | glycyrrhetinic acid is one of the deep processing series products of licorice extract. Licorice is commonly used in traditional Chinese medicine, widely used in medicine, tobacco, food and other fields. Its main active ingredient glycyrrhizic acid has adrenocorticotropic hormone-like effect, can be used for detoxification, anti-inflammatory, antitussive, anti-tumor and so on. The aglycone of glycyrrhizic acid is glycyrrhetinic acid. In human body, glycyrrhizic acid is hydrolyzed by gastric acid or decomposed by β-glucuronidase in liver to form glycyrrhetinic acid. |
| Application | The pharmacological action of glycyrrhizic acid is essentially that of glycyrrhetinic acid. In recent years, pharmacological studies have found that glycyrrhizic acid and glycyrrhetinic acid derivatives have anti-inflammatory, anti-ulcer, anti-allergic, antiviral, hypolipidemic, antitussive, Antiasthmatic, expectorant and other effects, can also be used for the prevention and treatment of viral hepatitis, diseases such as hyperlipidemia and cancer. China is the main export country of licorice. It is of great significance to carry out the deep processing and comprehensive utilization of licorice. |
| preparation | take glycyrrhizic acid powder (glycyrrhizic acid content about 25% HPLC) 95% G, add 1120ml of edible ethanol, extracting at 40 ℃ for 3 hours, filtering to remove insoluble impurities, distilling the filtrate to recover ethanol to obtain an extract, and setting the extract in a water bath to dry at 100 ℃ to obtain 118g of dry extract with a water content of not more than 20%; take 70% G of dry extract after crushing, add 103 glacial acetic acid, add 7ml of concentrated sulfuric acid, hydrolysis and acetylation under normal pressure, warm up to 98 ~ ℃, react for 2 hours, after completion of hydrolysis and acetylation, cool to room temperature, filter the precipitated solid, wash the filter cake with 65% ml of 100 acetic acid, then with ml of ethanol, and finally with ml of water, dry at °c, 20.21g of crude acetylglycyrrhetinic acid was obtained with a purity of 88.2%(HPLC). Take 20g of acetylglycyrrhetinic acid, add 300ml of water, add 5g of sodium hydroxide to adjust the pH to 13, reflux under normal pressure and hydrolyze for 4 hours, drop to room temperature, acidify the pH to 5.2 with hydrochloric acid, filter, wash the filter cake with pure water, the inorganic salt was removed and dried at 100 ° C. To obtain 17.8g of crude glycyrrhetinic acid with a purity of 92.9%(HPLC), and the crude glycyrrhetinic acid was dissolved in 95% volume% ethanol, according to the weight of crude glycyrrhetinic acid 25%(4.45g), add activated carbon for reflux decolorization, reflux decolorization after filtration, filtrate recovered ethanol, precipitated solid, filtered to obtain glycyrrhetinic acid 16.4g, purity 98.2% (neutralization method). To be further purified, recrystallized three times with 95% ethanol to obtain a glycyrrhetinic acid product with a purity of 98%(HPLC), with a total impurity peak not exceeding 2% and a single impurity peak not exceeding 0.7%, in full compliance with the standards of the European Pharmacopoeia. |
| principle of action | has anti-bacterial, anti-inflammatory, anti-oxidation, anti-aging, UV absorption, skin whitening, freckle and other effects; can regulate the skin immune function, enhance the skin disease resistance, eliminate inflammation, prevent allergies, clean the skin to prevent the production of melanin, with whitening effect. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 2450 mg/kg; Intraperitoneal-rat LD50: 128 mg/kg |
| flammability hazard characteristics | burning irritant smoke; Side effects of the drug: muscle weakness, weakness, paralysis, paralysis |
| storage and transportation characteristics | ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-09 20:49:11
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View History
glycyrrhetinic acid hydrogen succinate
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1245943-35-4
90564-77-5
Benzenamine, 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-
773786-39-3
2,4-Dichlor-3-ethyl-6-(2,4-di-tert.-butylphenoxi)-hexanoylamino)-phenol
15763-48-1
Ethanimidamide, N,N-dimethyl-N'-(1,2,3,4-tetrahydro-5-isoquinolinyl)-
3-cyclopentyl-N-(4-fluorobenzyl)propanamide
1347702-71-9