glaucocalyxin B
glaucocalyxin B
CAS: 80508-81-2
Molecular Formula: C22H30O5
glaucocalyxin B - Names and Identifiers
glaucocalyxin B - Physico-chemical Properties
| Molecular Formula | C22H30O5 |
| Molar Mass | 374.48 |
| Density | 1.21±0.1 g/cm3(Predicted) |
| Melting Point | 190.5-191℃ |
| Boling Point | 509.1±50.0 °C(Predicted) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | White crystalline powder |
| pKa | 13.42±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from Labiatae plant blue calyx fragrant tea vegetable Rabdosia japonica whole grass, Rabdosia rubescens. |
| In vitro study | Glaucocalyxin A (GlnA) and (GlnB) dose-dependently decrease the growth of HL-60 cells with an IC 50 of approximately 6.15 and 5.86 µM at 24 h, respectively. Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA damage and the accumulation of reactive oxygen species (ROS) in HL-60 cells. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis andautophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose dependent manner. GlnB increases the apoptotic cell population of and enhanced poly (ADP ribose) polymerase 1 cleavage. GlnB also induces increased light chain 3 II/I protein cleavage, indicating the induction of autophagy. GlnB treatment increases the expression of phosphatase and tensin homolog and decreases the expression of phosphorylated protein kinase B. Glaucocalyxin B (GLB), one of five ent-kauranoid diterpenoids, significantly decreased the generation of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-activated microglia cells. |
glaucocalyxin B - Reference Information
| biological activity | Glaucocalyxin B is an enantiomeric-kaurane-type diterpene isolated from a traditional Chinese medicine, has anti-cancer and anti-inflammatory activity. The IC50 value for HL-60 growth reduction in 24h was approximately 5.86 μm. |
| Target | IC50: 5.86 μm (HL-60 cell Growth) |
| in vitro study | Glaucocalyxin A (GlnA) and (GlnB) dose-dependently the growth of HL-60 cells with an IC 50 of approval 6.15 and 5.86 µm at 24 h, review. Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA brain and the accumulation of reactive Gen species (ROS) in HL-60 cells. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis andautophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose dependent manner. GlnB increases the apoptotic cell population of and enhanced poly (ADP ribose) polymerase 1 cleavage. GlnB also induces increased light chain 3 II/ I protein cleavage, indicating the induction of autophagy. GlnB treatment increases the expression of phosphatase and tensin homolog and decreases the expression of phosphorylated protein kinase B. Glaucocalyxin B (GLB), one of five ent-kauranoid diterpenoids, significantly decreased the generation of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-activated microglia cells. |
| Chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, it is derived from Labiatae plants Rabdosia herb Rabdosia, Rabdosia rubescens. |
| Use | cyanocalyxin B has the effects of anti-platelet aggregation and inhibiting cancer cells. |
Last Update：2024-04-09 21:21:28
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glaucocalyxin B
4-((5-氯-6-氧代-1-苯基-1,6-二氢哒嗪-4-基)氧基)-3-乙氧基苯甲醛
Propane, 2,2-bis[(1-methylethyl)thio]-
1-丁基-3-甲基咪唑对甲苯磺酸盐
[(4-Bromo-1-methyl-1H-pyrazol-5-yl)methyl]amine hydrobromide
TFMB (S) 2 HG
2-溴-1-[3,5-二(叔丁基)-4-羟基苯基]-1-乙酮
Bicyclo[2.2.1]hept-2-ene, 5-[2-(trimethoxysilyl)ethyl]-
(4R,5S,6S)-6-[(1R)-1-羟乙基]-3-二苯基磷酰氧基-2-青霉烯-2羧酸对硝基苄基酯
TAK-243 (MLN7243)
4-((5-氯-6-氧代-1-苯基-1,6-二氢哒嗪-4-基)氧基)-3-乙氧基苯甲醛
Propane, 2,2-bis[(1-methylethyl)thio]-
1-丁基-3-甲基咪唑对甲苯磺酸盐
[(4-Bromo-1-methyl-1H-pyrazol-5-yl)methyl]amine hydrobromide
TFMB (S) 2 HG
2-溴-1-[3,5-二(叔丁基)-4-羟基苯基]-1-乙酮
Bicyclo[2.2.1]hept-2-ene, 5-[2-(trimethoxysilyl)ethyl]-
(4R,5S,6S)-6-[(1R)-1-羟乙基]-3-二苯基磷酰氧基-2-青霉烯-2羧酸对硝基苄基酯
TAK-243 (MLN7243)