fmoc-l-2-iodophenylalanine is an amino acid derivative with the following properties and characteristics:
Nature:
1. Molecular formula: C35H31IN2O5
2. Molecular Weight: 676.53g/mol
3. Appearance: white to light yellow crystal
4. Solubility: Soluble in organic solvents such as dichloromethane, dimethyl sulfoxide and dimethylformamide, insoluble in water.
Use:
1. fmoc-l-2-iodophenylalanine is usually used as a protecting group strategy in polypeptide synthesis, mainly as a protecting group for amino acid residues.
2. It can be used to synthesize peptides or proteins with specific sequences, and has important application value in drug development and biochemical research.
3. It can also be used to synthesize small molecule compounds with biological activity, such as antitumor agents, antibacterial agents and enzyme inhibitors.
Method:
The preparation of fmoc-l-2-iodophenylalanine can be carried out by the following steps:
1. First, Fmoc-protected L-phenylalanine and an iodinating agent are reacted together to obtain a fmoc-l-2-iodophenylalanine.
2. The product is then purified by crystallization, washing and drying.
Safety Information:
1. fmoc-l-2-iodophenylalanine in the operation of the need to take appropriate safety measures, such as wearing protective clothing, gloves and protective glasses, avoid contact with the skin and inhalation of powder.
2. In storage, it should be kept in a dry, cool place, and away from fire and oxidant.
3. Pay attention to comply with the relevant safety operation regulations of chemicals during use, such as the correct handling and disposal of chemical wastes.