cis-4-Hydro×y-D-proline hydrochloride

cis-4-Hydro×y-D-proline hydrochloride - Names and Identifiers

Name	(2R,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acidhydrochloride
Synonyms	cis-D-Hyp-OH.HCl H-D-cis-Hyp-OH.HCL CIS-4-HYDROXY-D-PROLINE HCL cis-4-Hydroxy-D-proline hydrochloride cis-4-Hydro×y-D-proline hydrochloride (2R,4R)-4-hydroxyproline hydrochloride (2R,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acidhydrochloride (2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride cis-4-Hydroxy-D-proline hydrochloride ((2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride)
CAS	77449-94-6
EINECS	1592732-453-0
InChI	InChI=1/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/m1./s1

cis-4-Hydro×y-D-proline hydrochloride - Physico-chemical Properties

Molecular Formula	C5H10ClNO3
Molar Mass	167.5908
Melting Point	114-116 °C
Boling Point	368.6°C at 760 mmHg
Flash Point	176.7°C
Vapor Presure	6.22E-07mmHg at 25°C
Storage Condition	Inert atmosphere,Room Temperature

cis-4-Hydro×y-D-proline hydrochloride - Risk and Safety

HS Code

29339900

cis-4-Hydro×y-D-proline hydrochloride - Introduction

(2R,4R)-Acidhydrochloride is also known as D-hydrochloride or hydrochloride Acid, the chemical formula is C5H10N2O3 · HCl. The following is a description of some properties, uses, preparation and safety information about the compound:

Nature:
-Appearance: White crystalline powder
-Melting point: 170-175°C
-Solubility: Soluble in water and alcohol, slightly soluble in ether and chloroform
-Chemical properties: It is a carboxylic acid hydrochloride with acidic properties and can react with other compounds under alkaline conditions.

Use:
-Drug synthesis:(2R,4R)-Acidhydrochloride is a commonly used raw material compound, which is widely used in drug synthesis. It can be used to synthesize peptides, proteins and other biologically active molecules.
-Organic synthesis: This compound can be used as a chiral intermediate and plays an important catalytic and selective role in organic synthesis.

Preparation Method:
(2R,4R)-Acidhydrochloride can be synthesized by the following steps:
1. 2-chlorobutanoyl chloride reacts with L-proline under alkaline conditions to generate 2-chlorobutanoyl-L-proline.
2. 2-chlorobutanoyl-L-proline was reacted with enantioselective prolase to obtain 4-chloro-2-(2-hydroxyethyl) pyrroline-3-carboxyacyl-D-proline.
3. Finally, 4-chloro-2-(2-hydroxyethyl) pyrroline-3-carboxyl-D-proline was reacted with hydrochloric acid to obtain (2R,4R)-azide Acidhydrochloride.

Safety Information:
(2R,4R)-The safety information of the Acidhydrochloride is not completely clear, so it is necessary to follow the relevant laboratory safety operation specifications during use. It is recommended to wear appropriate protective gloves and glasses when using the compound to avoid direct contact with the mouth and skin. If the contact causes discomfort or adverse reactions, should immediately seek medical advice.

Last Update：2024-04-09 21:00:56

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