Name | boc-L-alpha-phenylglycine |
Synonyms | Boc-Phg-OH Boc-L-Phg-OH Boc-L-phenylglycine N-Boc-L-phenylglycine (S)-Boc-L-Phenylglycine boc-L-alpha-phenylglycine (Tert-Butoxy)Carbonyl Phg-OH (S)-Boc-2-aminophenylacetic acid N-Boc-L-2-phenylglycineBoc-Phg-OH 2-(tert-butoxycarbonyl)-2-phenylacetic acid N-alpha-tert-Butoxycarbonyl-L-phenylglycine [(tert-butoxycarbonyl)amino](phenyl)acetic acid Boc-Phg-OH~N-(tert-Butoxycarbonyl)-L-phenylglycine (2S)-[(tert-butoxycarbonyl)aMino](phenyl)ethanoic acid (2S)-[(tert-butoxycarbonyl)amino](phenyl)ethanoic acid (2R)-[(tert-butoxycarbonyl)amino](phenyl)ethanoic acid (S)-2-((tert-Butoxycarbonyl)aMino)-2-phenylacetic acid |
CAS | 2900-27-8 |
EINECS | 000-000-0 |
InChI | InChI=1/C13H17NO4/c1-13(2,3)18-12(17)14-10(11(15)16)9-7-5-4-6-8-9/h4-8,10H,1-3H3,(H,14,17)(H,15,16)/t10-/m0/s1 |
Molecular Formula | C13H17NO4 |
Molar Mass | 251.28 |
Density | 1.182±0.06 g/cm3(Predicted) |
Melting Point | 88-91°C |
Boling Point | 407.2±38.0 °C(Predicted) |
Specific Rotation(α) | 142 ° (C=1, EtOH) |
Flash Point | 200.1°C |
Water Solubility | Insoluble in water |
Vapor Presure | 2.32E-07mmHg at 25°C |
Appearance | White crystal |
Color | White to Almost white |
BRN | 3592362 |
pKa | 3.51±0.10(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
Refractive Index | 142 ° (C=1, EtOH) |
MDL | MFCD00065588 |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 2924 29 70 |
Application | N-(tert-butoxycarbonyl)-L-2-phenylglycine is an amino acid derivative, as an important raw material compound and drug intermediate, It can be used to synthesize β-lactam antibiotics such as penicillin, vilamycin, and prenamycin I , and can also be used for the synthesis of anti-tumor drug violet. N-(tert-butoxycarbonyl)-L-2-phenylglycine is its N-protected product and is widely used in pharmaceutical and chemical industries. |
Synthesis method | Using L-2-phenylglycine as raw material, it reacts with di-tert-butyl dicarbonate under Et 3 N/MeOH conditions for Boc protection to prepare the target compound N-(tert-butoxycarbonyl)-L-2-phenylglycine. The preparation reaction formula of N-(tert-butoxycarbonyl)-L-2-phenylglycine is as follows: |