benzene-1,2-diol hydrochloride
Dobutamine HCL
CAS: 49745-95-1
Molecular Formula: C18H24ClNO3
benzene-1,2-diol hydrochloride - Names and Identifiers
benzene-1,2-diol hydrochloride - Physico-chemical Properties
| Molecular Formula | C18H24ClNO3 |
| Molar Mass | 337.84 |
| Melting Point | 184-186 C |
| Boling Point | 263.8°C at 760 mmHg |
| Flash Point | 113.3°C |
| Water Solubility | Soluble in water or ethanol with warming. Also soluble in methanol |
| Solubility | Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent). |
| Vapor Presure | 0.00617mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['281nm(MeOH)(lit.)'] |
| Merck | 14,3395 |
| pKa | 9.45(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light. |
| Use | Anti-Shock drugs for heart failure due to decreased myocardial contractility in organic heart disease |
benzene-1,2-diol hydrochloride - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R63 - Possible risk of harm to the unborn child R36/37/38 - Irritating to eyes, respiratory system and skin. R62 - Possible risk of impaired fertility R11 - Highly Flammable R21 - Harmful in contact with skin R20 - Harmful by inhalation |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves. S53 - Avoid exposure - obtain special instructions before use. S39 - Wear eye / face protection. S37 - Wear suitable gloves. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29222990 |
| Toxicity | LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle) |
benzene-1,2-diol hydrochloride - Standard
Authoritative Data Verified Data
This product is 4-[2-[[l-methyl -3-(4-hydroxyphenyl) propyl] amino] ethyl]-1, 2-benzenediol hydrochloride. Calculated as dry product, containing no less than 98.5% of C18H23N03 • HCl.
Last Update：2024-01-02 23:10:35
benzene-1,2-diol hydrochloride - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Almost odorless; In open air and in light color gradient deep.
- This product is slightly soluble in water or anhydrous ethanol, and almost insoluble in chloroform.
melting point
The melting point of this product (General 0612) is 188~193°C.
Last Update：2022-01-01 14:23:13
benzene-1,2-diol hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.96 ml | 14.8 ml | 29.6 ml |
| 5 mM | 0.592 ml | 2.96 ml | 5.92 ml |
| 10 mM | 0.296 ml | 1.48 ml | 2.96 ml |
| 5 mM | 0.059 ml | 0.296 ml | 0.592 ml |
Last Update：2024-01-02 23:10:35
benzene-1,2-diol hydrochloride - Differential diagnosis
Authoritative Data Verified Data
- take about 10mg of this product, add 2ml of water to dissolve, add 1 drop of ferric chloride test solution, the solution is green, and then add 1 drop of ammonia test solution, which turns to blue-purple, purple, and finally purple-red.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 346).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 14:23:14
benzene-1,2-diol hydrochloride - Exam
Authoritative Data Verified Data
acidity
take the solution under the clarity of the solution, measured by law (General 0631), the pH value should be 4.5~6.0.
clarity of the solution
take 0.10g of this product and add 10ml of newly boiling cold water to dissolve. The solution should be clarified.
color of solution
take this product, add methanol-water (1:1) to dissolve and dilute to make a solution containing 20mg per 1 mL (if necessary, can be dissolved at 30~35°C), quickly cooled to room temperature, according to UV-visible spectrophotometry (General 0401), absorbance values at 480mn wavelength should not be greater than 0.04.
Related substances
take this product, add mobile phase A- mobile phase B(65:35) to dissolve and dilute to make A solution containing about 5mg per 1ml as A test solution; Take 1ml for precision measurement, in A 100ml measuring flask, dilute to the scale with mobile phase A- mobile phase B(65:35), and shake to A control solution. According to the high performance liquid chromatography (General rule 0512) test, silica gel bonded with eighteen alkyl silane was used as filler; Sodium octane sulfonate 2.6g was added with ml of water to dissolve, triethylamine 3ml was added, and the solution was shaken, the mobile phase A was adjusted to pH 2.5 with phosphoric acid; The mobile phase B was acetonitrile-methanol (18:82); Gradient elution was carried out as follows; The detection wavelength was 280nm. The number of theoretical plates shall not be less than 2000 calculated as dobutamine peak. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatograms were recorded. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
residual solvent
take this product, precision weighing, plus N,N-dimethylformamide dissolution and quantitative dilution made from each lml containing about 0.lg of the solution, as a test solution; Another take benzene and acetone, precision weighing, quantitative dilution with N,N-dimethylformamide to make a mixed solution containing about 0.2ug of benzene and acetone 0.5mg per 1 ml, as a control solution. According to the test for determination of residual solvents (General rule 0861 third method), 100% polydimethylpolyoxysilane (or similar polarity) was used as the stationary liquid, and the initial temperature was 40°C, which was maintained for 5 minutes, the temperature was raised to 260°C at a rate of 20°C per minute for 3 minutes; The inlet temperature was 200°C; And the detector temperature was 270°C. Take 1ul of the reference solution and inject it into the gas chromatograph. The separation degree between the peaks of each component shall meet the requirements. Then, 1ul of the test solution and the reference solution are accurately measured, respectively injected into the human gas chromatograph, and the chromatogram is recorded. According to the external standard method to calculate the peak area, the residual amount of benzene and acetone should be in accordance with the provisions.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 14:23:15
benzene-1,2-diol hydrochloride - Content determination
Authoritative Data Verified Data
take this product about 0.25g, precision weighing, add anhydrous formic acid 10ml to dissolve, plus acetic anhydride 50ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 33.79mg of C18H23N03. Hc1.
Last Update：2022-01-01 14:23:15
benzene-1,2-diol hydrochloride - Category
Authoritative Data Verified Data
B-adrenoceptor agonists.
Last Update：2022-01-01 14:23:15
benzene-1,2-diol hydrochloride - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 14:23:16
benzene-1,2-diol hydrochloride - Dobutamine hydrochloride injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of dobutamine hydrochloride. The content of dobutamine hydrochloride (C18H23N03 • HC1) shall be between 90.0% and 110.0% of the indicated amount calculated as dobutamine (C18H23N03).
trait
This product is a clear colorless liquid.
identification
- take this product, add 1 drop of ferric chloride test solution, the solution is green, and then add 1 drop of ammonia test solution, which will turn blue-purple and purple, and finally appear purple-red.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- This product chloride identification (1) of the reaction (General 0301).
examination
- the pH value should be 2.5 to 5.0 (General 0631).
- precise measurement of related substances take 5ml of this product, put it in A 10ml measuring flask, dilute it to the scale with mobile phase A- mobile phase B(65:35), shake it well, and use it as A test solution; take 1ml accurately, put it in A 100ml measuring flask, dilute to the scale with mobile phase A- mobile phase B(65:35), and shake to obtain A control solution. Determination of dobutamine hydrochloride related substances according to the method. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- bacterial endotoxin take this product, according to the law inspection (General 1143), each 1 mg dobutamine hydrochloride containing endotoxin amount should be less than 1.2EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Sodium octane sulfonate 2.6g, add water 1000ml to dissolve, add triethylamine 3ml, shake, the pH was adjusted to 2.5 with phosphoric acid as mobile phase A; Acetonitrile-methanol (18:82) as mobile phase B; Mobile phase A- mobile phase B(55:45) as mobile phase; The detection wavelength was 280nm. Take 4-(4-hydroxyphenyl)-2-butanone (impurity I) control and dobutamine hydrochloride control, add mobile phase to dissolve into mixed solution containing 0.3mg and 0.5mg respectively in each lml, take 20u1 injection human liquid chromatograph, record chromatogram, the number of theoretical plate shall not be less than 2000 according to dobutamine peak, the resolution of the dobutamine peak from the impurity I peak should be satisfactory.
- precision measurement 5ml of this product is placed in a 100ml measuring flask, diluted to the scale with mobile phase, shaken well, and used as a test solution. 20ul of the precision measurement is injected into the liquid chromatograph, record the chromatogram; Take appropriate amount of dobutamine hydrochloride reference substance, precise weighing, and add mobile phase to make a solution containing 0.5mg dobutamine per 1 ml. According to the external standard method to calculate the peak area, that is.
category
Same as dobutamine hydrochloride.
specification
2ml:20mg (based on C18H23N03)
storage
light shielding, closed storage.
Last Update：2022-01-01 14:23:17
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View History
benzene-1,2-diol hydrochloride
N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-[2-methoxy(methylsulfonyl)anilino]acetamide
1H-Indole,5-chloro-2,3-dihydro-7-methyl-2-(4-pyridinyl)-(9CI)
1086392-22-4
5930-98-3
743477-68-1
6-NITRO-N-(PYRIDIN-2-YLMETHYL)-1,3-BENZOTHIAZOL-2-AMINE
propyl 2-{[(3,5-dimethylphenoxy)acetyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
BIO-FARMA BF001233
56773-33-2
N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-[2-methoxy(methylsulfonyl)anilino]acetamide
1H-Indole,5-chloro-2,3-dihydro-7-methyl-2-(4-pyridinyl)-(9CI)
1086392-22-4
5930-98-3
743477-68-1
6-NITRO-N-(PYRIDIN-2-YLMETHYL)-1,3-BENZOTHIAZOL-2-AMINE
propyl 2-{[(3,5-dimethylphenoxy)acetyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
BIO-FARMA BF001233
56773-33-2