Molecular Formula | C13H18Br2N2O |
Molar Mass | 378.1 |
Density | 1.5863 (rough estimate) |
Melting Point | 233-234 C |
Boling Point | 468.6±45.0 °C(Predicted) |
Flash Point | 237.23°C |
Solubility | Soluble in Water. |
Vapor Presure | 0mmHg at 25°C |
Appearance | solid |
Color | White |
pKa | 15.12±0.40(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
Refractive Index | 1.6220 (estimate) |
Physical and Chemical Properties | Ambroxol hydrochloride: C13H18Br2N2O? HCl. [23828-92-4]. Crystallization from ethanol, melting point 233~234.5 °c (decomposition). Acute toxicity LD50 mice, rats (mg/kg):268,380 intraperitoneal injection; 2720,13400 oral. |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | GV8423000 |
from ethanol crystallization, melting point 233~234,5 degrees C (decomposition).
methyl anthranilate, dichloroethane, water and concentrated sulfuric acid were mixed, bromine was added dropwise at room temperature, and reaction was carried out, and 30% hydrogen peroxide was added to react. 10% sodium sulfite was added dropwise until the brown color was removed and treated to give the dibromide. The dibromide was refluxed with ethylene glycol monoether, hydrazine hydrate. After cooling to room temperature, the crystals were collected by filtration and recrystallized from methanol to obtain the hydrazide. The hydrazide compound was dissolved in dioxane and pyridine, and methanesulfonyl chloride was added dropwise. The reaction was completed, and the treatment was carried out to obtain a methanesulfonyl hydrazide derivative. Mix 1-4-aminocyclohexanol hydrochloride, sodium hydroxide, potassium carbonate and ethylene glycol monomethyl ether, add methanesulfonyl hydrazide derivative in portions, reflux, complete reaction, the compound obtained by the treatment was subjected to hydrogenation reaction with glacial acetic acid and palladium-carbon, and finally Ambroxol hydrochloride crystals were obtained.
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.645 ml | 13.224 ml | 26.448 ml |
5 mM | 0.529 ml | 2.645 ml | 5.29 ml |
10 mM | 0.264 ml | 1.322 ml | 2.645 ml |
5 mM | 0.053 ml | 0.264 ml | 0.529 ml |
developed in Germany by Boehnnger Ingelheim. Expectorant for thinning phlegm. It has the function of promoting mucus elimination and dissolving secretions. It can promote the elimination of viscous secretions in the respiratory tract and reduce the retention of mucus, thus significantly promoting sputum excretion and improving respiratory condition. When the patient is treated with the product, the secretion of mucus can be restored to normal condition. Cough and sputum volume is usually significantly reduced, the respiratory mucosa of the surface active substance can thus play its normal protective function. It is suitable for acute and chronic respiratory diseases with abnormal secretion of sputum and poor expectoration function. For the treatment of acute and chronic respiratory diseases, abnormal bronchial secretion.
mouse, rat LD50( mg/kg):268,380 intraperitoneal injection; 2720, 13400 orally.