alpha-Cyperone (α-Cyperone)
alpha-Cyperone
CAS: 473-08-5
Molecular Formula: C15H22O
alpha-Cyperone (α-Cyperone) - Names and Identifiers
| Name | alpha-Cyperone |
| Synonyms | α-cyperon A-CYPERONE α-cyperone alpha-Cyperone α-Cyperone 473-08-5 alpha-Cyperone (α-Cyperone) (4aS,7R)-1,4a-Dimethyl-7-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalen-2-one (4aS,7R)-1,4a-dimethyl-7-(1-methylethenyl)-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one (4aS-cis)-4,4a,5,6,7,8-Hexahydro-1,4a-dimethyl-7-(1-methylethenyl)-2(3H)-naphthalenone |
| CAS | 473-08-5 |
| InChI | InChI=1/C15H22O/c1-10(2)12-5-7-15(4)8-6-14(16)11(3)13(15)9-12/h12H,1,5-9H2,2-4H3/t12-,15+/m1/s1 |
alpha-Cyperone (α-Cyperone) - Physico-chemical Properties
| Molecular Formula | C15H22O |
| Molar Mass | 218.33 |
| Density | 0.9946 g/cm3(Temp: 25 °C) |
| Melting Point | 232 °C |
| Boling Point | 177 °C(Press: 20 Torr) |
| Specific Rotation(α) | 138 |
| Flash Point | 142.8°C |
| Solubility | Soluble in methanol and water |
| Vapor Presure | 0.000319mmHg at 25°C |
| Appearance | oily liquid |
| Color | Colourless to Pale Yellow |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Sensitive | Avoid light |
| Refractive Index | 1.503 |
| MDL | MFCD09839027 |
| Physical and Chemical Properties | Yellow liquid, soluble in methanol and water, derived from the rhizome of Cyperus rotunus L. |
| In vitro study | The anti-inflammatory activity of alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells. alpha-Cyperone (α-Cyperone) binds and interacts with tubulin and is capable of distinctly destabilizing microtubule polymerization. The effect of this interaction could result in reduction of inflammation which would be highly beneficial for treatment of inflammatory diseases such as AD. One microliter of alpha-Cyperone was dissolved in DMSO (1:1 v/v) and it was further diluted in double distilled water (ddH2O) to a final volume of 20 microliter. |
alpha-Cyperone (α-Cyperone) - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29143990 |
alpha-Cyperone (α-Cyperone) - Reference
| Reference Show more | 1. Zhang Jingzhi, Zhao Danqing, Wang Zhengrong, etc. Simultaneous determination of the contents of seven active ingredients in Yao Yao yuili Yao mi spray by one-Test multi-evaluation method [J]. China Pharmacy, 2020(9). 2. A jade butterfly, Li Qin, Song morning pigeon, Chen Tian, Ma Yanjiang. Optimization of processing technology and quantitative study of processing endpoint of vinegar-fried Rhizoma cyperi based on multi-index response surface methodology [J]. Chinese herbal medicine, 2021,52(04):982-992. 3. [IF = 3.263] Xiao-Dong Pei et al."Alpha-cyperone inhibitors of human cerical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway." Eur J Pharmacol. 2020 Sep;883:173355 |
alpha-Cyperone (α-Cyperone) - Reference Information
| introduction | alpha-Cyperone is a yellow liquid, easily soluble in methanol and water, and comes from the rhizome of Cyperus sylvestris, Cyperaceae plant Cyperus sylvestris (Cyperus sylvestris) Cyperus rotundus L. |
| biological activity | α-Cyperone (alpha-cyperone) is the main active ingredient of aconite Cyperus rotundus, showing biological activities such as antitoxicity, antigenic toxicity and antibacterial activity. α-Cyperone (alpha-cyperone) is related to down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1. |
| use | α-Cyperone has antipyretic and analgesic effects. used for content determination/identification/pharmacological experiments and other pharmacological effects: soothing liver and relieving depression, nourishing blood, regulating meridian and relieving pain |
Last Update：2024-04-09 21:11:58
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View History
alpha-Cyperone (α-Cyperone)
3环己烯甲酸3环己烯甲酯
AMMONIUM AQUOPENTACHLORORUTHENATE(III)
Demiditraz Impurity 4
2-甲基-2-丙基[(2R)-1-氰基-2-丙基]氨基甲酸酯
2-Chloro-4-Iodobenzoic Acid
甲基苯并[d]噁唑-7-羧酸甲酯
3-Amino-3-(2,4,6-trichlorophenylhydrazono)propionic acid ethyl ester
4-异丙基嘧啶-5-胺二盐酸盐
丙烯酸-2-乙基己酯、甲基丙烯酸甲酯的聚合物
3环己烯甲酸3环己烯甲酯
AMMONIUM AQUOPENTACHLORORUTHENATE(III)
Demiditraz Impurity 4
2-甲基-2-丙基[(2R)-1-氰基-2-丙基]氨基甲酸酯
2-Chloro-4-Iodobenzoic Acid
甲基苯并[d]噁唑-7-羧酸甲酯
3-Amino-3-(2,4,6-trichlorophenylhydrazono)propionic acid ethyl ester
4-异丙基嘧啶-5-胺二盐酸盐
丙烯酸-2-乙基己酯、甲基丙烯酸甲酯的聚合物