Upadacitinib intermediate
(3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester
CAS: 1428243-26-8
Molecular Formula: C16H20BrNO3
Upadacitinib intermediate - Names and Identifiers
Upadacitinib intermediate - Physico-chemical Properties
| Molecular Formula | C16H20BrNO3 |
| Molar Mass | 354.24 |
| Density | 1.361±0.06 g/cm3(Predicted) |
| Boling Point | 453.1±45.0 °C(Predicted) |
| pKa | -2.91±0.60(Predicted) |
Upadacitinib intermediate - References
| Introduction | (3R,4S)-3-(2-bromoacetyl) benzyl 4-ethyl-1-pyrrolidinecarboxylate is a key intermediate for upatinib. In early 2018, Upadacitinib (ABT-494), a once-daily selective JAK1 inhibitor for the treatment of moderate to severe atopic dermatitis in adults, obtained FDA breakthrough therapy approval. |
| Use | (3R,4S)-3-(2-bromoacetyl) 4-ethyl-1-pyrrolidine carboxylic acid benzyl ester is a carboxylic acid ester-based organic compound that can be used as a key intermediate for upatinib. |
Last Update：2024-04-09 02:00:15
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Product Name: (3R4S)-3-(2-溴乙酰基)-4- 乙基- 1-吡咯烷羧酸苄酯 Visit Supplier Webpage Request for quotationCAS: 1428243-26-8
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Product Name: Benzyl(3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate Visit Supplier Webpage Request for quotationCAS: 1428243-26-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Spot supply
Product Name: (3R4S)-3-(2-溴乙酰基)-4- 乙基- 1-吡咯烷羧酸苄酯 Visit Supplier Webpage Request for quotationCAS: 1428243-26-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Benzyl(3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate Visit Supplier Webpage Request for quotationCAS: 1428243-26-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
Upadacitinib intermediate
对溴苯基氯硫代甲酸酯
4-碘苯氧基乙酸
玛伐凯泰杂质31
丙烯酸-2-乙基己酯、甲基丙烯酸甲酯的聚合物
对羧基苯基硫脲
Propanedinitrile, 2-[amino(1-methylethoxy)methylene]-
三甲基硅甲基三氟甲磺酸酯
2,5-二丙氧基对苯二酰肼
硬脂基二甲铵羟丙基水解丝蛋白
对溴苯基氯硫代甲酸酯
4-碘苯氧基乙酸
玛伐凯泰杂质31
丙烯酸-2-乙基己酯、甲基丙烯酸甲酯的聚合物
对羧基苯基硫脲
Propanedinitrile, 2-[amino(1-methylethoxy)methylene]-
三甲基硅甲基三氟甲磺酸酯
2,5-二丙氧基对苯二酰肼
硬脂基二甲铵羟丙基水解丝蛋白