Trilaciclib (G1T28)
2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one
CAS: 1374743-00-6
Molecular Formula: C24H30N8O
Trilaciclib (G1T28) - Names and Identifiers
| Name | 2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one |
| Synonyms | G1T28 G1T-28 G1T 28 TRILACICLIB. Trilaciclib (G1T28) |
| CAS | 1374743-00-6 |
Trilaciclib (G1T28) - Physico-chemical Properties
| Molecular Formula | C24H30N8O |
| Molar Mass | 446.55 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| pKa | 13.33±0.20(Predicted) |
| Storage Condition | Room Temprature |
| In vitro study | Incubation with Trilaciclib (G1T28) for 24 hours induces a robust G 1 cell-cycle arrest (time=0). By 16 hours after Trilaciclib hydrochloride washout, cells have reentered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells. These results demonstrate that Trilaciclib causes a transient, and reversible G 1 arrest. A transient Trilaciclib-mediated G 1 cell-cycle arrest in CDK4/6-sensitive cells decreases the in vitro toxicity of a variety of commonly used cytotoxic chemotherapy agents associated with myelosuppression. |
| In vivo study | Trilaciclib (G1T28) treatment results in a robust and dose-dependent suppression of proliferation in HSPCs at 12 hours, with EdU incorporation returning near baseline levels in a dose-dependent manner by 24 hours after administration. These data demonstrate that a single oral dose of Trilaciclib can produce reversible cell-cycle arrest in HSPCs in a dose-dependent manner in vivo . Mice given 100 mg/kg Trilaciclib 30 minutes prior to etoposide treatment, exhibits only background levels of caspase-3/7 activity. These data demonstrate that Trilaciclib can protect the bone marrow from chemotherapy-induced apoptosis in vivo . The data demonstrate that treatment with Trilaciclib prior to 5-FU likely decreases 5-FU-induced damage by chemotherapy in HSPCs, thus accelerating blood count recovery after chemotherapy. |
Trilaciclib (G1T28) - Introduction
2 '-((5-(4-Methylpiperazin-1-yl) pyridin-2-yl) amino)-7',8 '-dihydro-6'h-spiro [cyclohexane -1,9'-Pyrazino [1 ',2':1,5] pyrrole [2,3-d] pyrrole] is an organic compound. The following is a brief description of the properties, uses, preparation and safety information of the compound:
Nature:
-Molecular formula: C26H33N7
-Molecular weight: 455.59g/mol
-Appearance: colorless crystalline powder
-Melting point: About 220-222 ° C
-Soluble: Soluble in DMSO and ethyl formate, almost insoluble in water
Use:
- 2 '-((5-(4-Methylpiperazin-1-yl) pyridin-2-yl) amino)-7',8 '-Dihydro-6'h-spiro [cyclohexane -1,9'-pyrazino [1 ',2':1,5] pyrrole [2,3-d] pyrrole] is a multifunctional intermediate compound that can be used to synthesize other organic compounds.
-In the medical field, it may have pharmacological activities such as anti-tumor and anti-virus, but further research is still needed to confirm its specific application.
Preparation Method:
-Due to the complex structure of the compound, the preparation method may be relatively complicated. Specialized knowledge and skill in organic synthetic chemistry is usually required, and may require multiple reactions and special reagents.
Safety Information:
-As the compound is still in the research stage, the details of its safety may not be fully understood.
-When handling and using the compound, it is recommended to follow appropriate laboratory safety procedures, such as wearing personal protective equipment (such as gloves and glasses) and operating in a well-ventilated environment, avoid direct contact with skin, eyes and mouth.
-If the compound needs to be used in the laboratory or other places, please conduct relevant toxicological evaluation and risk assessment first, and handle it in strict accordance with safe operating procedures.
Nature:
-Molecular formula: C26H33N7
-Molecular weight: 455.59g/mol
-Appearance: colorless crystalline powder
-Melting point: About 220-222 ° C
-Soluble: Soluble in DMSO and ethyl formate, almost insoluble in water
Use:
- 2 '-((5-(4-Methylpiperazin-1-yl) pyridin-2-yl) amino)-7',8 '-Dihydro-6'h-spiro [cyclohexane -1,9'-pyrazino [1 ',2':1,5] pyrrole [2,3-d] pyrrole] is a multifunctional intermediate compound that can be used to synthesize other organic compounds.
-In the medical field, it may have pharmacological activities such as anti-tumor and anti-virus, but further research is still needed to confirm its specific application.
Preparation Method:
-Due to the complex structure of the compound, the preparation method may be relatively complicated. Specialized knowledge and skill in organic synthetic chemistry is usually required, and may require multiple reactions and special reagents.
Safety Information:
-As the compound is still in the research stage, the details of its safety may not be fully understood.
-When handling and using the compound, it is recommended to follow appropriate laboratory safety procedures, such as wearing personal protective equipment (such as gloves and glasses) and operating in a well-ventilated environment, avoid direct contact with skin, eyes and mouth.
-If the compound needs to be used in the laboratory or other places, please conduct relevant toxicological evaluation and risk assessment first, and handle it in strict accordance with safe operating procedures.
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: G1T28 Visit Supplier Webpage Request for quotationCAS: 1374743-00-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Trilaciclib Visit Supplier Webpage Request for quotationCAS: 1374743-00-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one Visit Supplier Webpage Request for quotation
CAS: 1374743-00-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1374743-00-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: G1T28 Visit Supplier Webpage Request for quotationCAS: 1374743-00-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Trilaciclib Visit Supplier Webpage Request for quotationCAS: 1374743-00-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one Visit Supplier Webpage Request for quotation
CAS: 1374743-00-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1374743-00-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Trilaciclib (G1T28)
1-(4-(2-(氮杂环庚烷-1-基)乙氧基)苄基)-5-(苄氧基)-2-(4-(苄氧基)苯基)-3-甲基-1H-吲哚
1-(1-乙基-5-甲基-1H-吡唑-4-基)-2-甲基丙烷-1-酮
BOC-D-2-氨基-3,3-二环丙基丙氨酸-(4-甲氧基)苄酯
1-氨基-3-(呋喃-2-基甲氧基)-丙-2-醇
4-甲基-8-羟基喹啉
4,4'-双(2,4-二氟苯基)-2,2'-联吡啶
2-(3-甲基-哌啶-1-基)-嘧啶-5-甲醛
5-叠氮基戊-1-醇
2-羟基-5-硝基苯甲醛
1-(4-(2-(氮杂环庚烷-1-基)乙氧基)苄基)-5-(苄氧基)-2-(4-(苄氧基)苯基)-3-甲基-1H-吲哚
1-(1-乙基-5-甲基-1H-吡唑-4-基)-2-甲基丙烷-1-酮
BOC-D-2-氨基-3,3-二环丙基丙氨酸-(4-甲氧基)苄酯
1-氨基-3-(呋喃-2-基甲氧基)-丙-2-醇
4-甲基-8-羟基喹啉
4,4'-双(2,4-二氟苯基)-2,2'-联吡啶
2-(3-甲基-哌啶-1-基)-嘧啶-5-甲醛
5-叠氮基戊-1-醇
2-羟基-5-硝基苯甲醛