Name | Tolterodine |
Synonyms | DETROL Kabi 2234 PNU 200583 DETRUSITOL Tolterodine 124937-51-5 (R)-Tolterodine R-(+)-Tolterodine 2-[3-(dipropan-2-ylamino)-1-phenylpropyl]-4-methylphenol 2-{3-[bis(1-methylethyl)amino]-1-phenylpropyl}-4-methylphenol 2-[(1S)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-methylphenol phenol, 2-[3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl- 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol 2-[3-(diisopropylamino)-1-phenyl-propyl]-4-methyl-phenol hydrochloride (R)-(+)-N,N-Diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine |
CAS | 124937-51-5 |
InChI | InChI=1/C22H31NO.ClH/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24;/h6-12,15-17,20,24H,13-14H2,1-5H3;1H |
Molecular Formula | C22H31NO |
Molar Mass | 325.49 |
Density | 1.003±0.06 g/cm3(Predicted) |
Boling Point | 442.2±45.0 °C(Predicted) |
Specific Rotation(α) | D25 +72° (c = 1.0 in CH2Cl2) |
Flash Point | 237.5°C |
Solubility | DMSO: ≥20mg/mL |
Vapor Presure | 2.02E-09mmHg at 25°C |
Appearance | powder |
Color | white to off-white |
pKa | pKa 9.8 (Uncertain) |
Storage Condition | -20°C Freezer |
Risk Codes | R63 - Possible risk of harm to the unborn child R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S57 - Use appropriate container to avoid environmental contamination. |
WGK Germany | 3 |
developed by Pharmacia & Upiohn, Inc., USA, which was first launched in Sweden in February 1998 and in the United Kingdom and the United States in the same year. It was launched in France in April 1999. Muscarinic receptor antagonists. For the treatment of bladder stimulation caused by urinary incontinence, urinary frequency and urgency and other symptoms.
male mice were injected intravenously with LDso: 10~20mg/kg.
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.072 ml | 15.362 ml | 30.723 ml |
5 mM | 0.614 ml | 3.072 ml | 6.145 ml |
10 mM | 0.307 ml | 1.536 ml | 3.072 ml |
5 mM | 0.061 ml | 0.307 ml | 0.614 ml |