Tert-butyl 5-Bromopyridin-2-ylcarbamate
2-(N-BOC-Amino)-5-Bromopyridine
CAS: 159451-66-8
Molecular Formula: C10H13BrN2O2
Tert-butyl 5-Bromopyridin-2-ylcarbamate - Names and Identifiers
| Name | 2-(N-BOC-Amino)-5-Bromopyridine |
| Synonyms | 2-(BOC-Amino)-5-Bromopyridine 2-(BOC-AMINO)-5-BROMOPYRIDINE N-Boc-2-amino-5-bromopyridine 2-(N-BOC-AMINO)-5-BROMOPYRIDINE 2-(N-BOC-Amino)-5-Bromopyridine TERT-BUTYL 5-BROMOPYRIDIN-2-YLCARBAMATE Tert-butyl 5-Bromopyridin-2-ylcarbamate 2-Amino-5-bromopyridine, 2-BOC protected 5-Bromo-2-(tert-butoxycarbonylamino)pyridine tert-butyl N-(5-bromo-pyridin-2-yl)carbamate tert-butyl (5-Bromopyridin-2-yl)-carbamic acid |
| CAS | 159451-66-8 |
| InChI | InChI=1/C10H13BrN2O2/c1-10(2,3)15-9(14)13-8-5-4-7(11)6-12-8/h4-6H,1-3H3,(H,12,13,14) |
| InChIKey | CKXAMCSVTNPSCZ-UHFFFAOYSA-N |
Tert-butyl 5-Bromopyridin-2-ylcarbamate - Physico-chemical Properties
| Molecular Formula | C10H13BrN2O2 |
| Molar Mass | 273.13 |
| Density | 1.453±0.06 g/cm3(Predicted) |
| Melting Point | 167-171°C(lit.) |
| Boling Point | 288.2±25.0 °C(Predicted) |
| Flash Point | 128.078°C |
| Vapor Presure | 0.002mmHg at 25°C |
| pKa | 11.68±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.573 |
| MDL | MFCD06411381 |
| Physical and Chemical Properties | WGK Germany:3 |
Tert-butyl 5-Bromopyridin-2-ylcarbamate - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
Tert-butyl 5-Bromopyridin-2-ylcarbamate - Introduction
2-(N-BOC-Amino)-5-Bromopyridine is an organic compound with the following properties:
1. Appearance: 2-(N-BOC-Amino)-5-Bromopyridine is a white solid.
2. Chemical properties: It is a basic compound, soluble in organic solvents such as dimethyl sulfoxide and dichloromethane. Its solubility in water is low.
3. Use: this compound is commonly used in organic synthesis of ammonia protecting group. Due to its stability, the amino group can be protected in organic synthesis and can be easily removed by deprotection reaction after the synthesis.
4. Preparation method: The preparation of 2-(N-BOC-Amino)-5-Bromopyridine can be carried out by the following steps:
a. First, 2-amino-5-bromopyridine is reacted with Boc2O (bis (t-propyl) oxyurea) in the presence of a base.
B. After completion of the reaction, the protecting group Boc was removed by adding water and adjusting the pH value.
c. Finally, the desired product can be obtained by crystallization purification and the like.
5. Safety information: in the operation and storage, need to pay attention to the following safety aspects:
a. Avoid inhalation, contact with skin, and ingestion of compounds.
B. Use should wear experimental gloves, experimental glasses and protective clothing.
c. Should be operated in a well ventilated place.
d. In case of skin contact, rinse immediately with plenty of water and seek medical help.
e. In case of accidental inhalation or ingestion, seek medical attention immediately.
f. The compound should be stored in a dry, cool, well-ventilated place, avoiding contact with oxygen, heat, and fire.
1. Appearance: 2-(N-BOC-Amino)-5-Bromopyridine is a white solid.
2. Chemical properties: It is a basic compound, soluble in organic solvents such as dimethyl sulfoxide and dichloromethane. Its solubility in water is low.
3. Use: this compound is commonly used in organic synthesis of ammonia protecting group. Due to its stability, the amino group can be protected in organic synthesis and can be easily removed by deprotection reaction after the synthesis.
4. Preparation method: The preparation of 2-(N-BOC-Amino)-5-Bromopyridine can be carried out by the following steps:
a. First, 2-amino-5-bromopyridine is reacted with Boc2O (bis (t-propyl) oxyurea) in the presence of a base.
B. After completion of the reaction, the protecting group Boc was removed by adding water and adjusting the pH value.
c. Finally, the desired product can be obtained by crystallization purification and the like.
5. Safety information: in the operation and storage, need to pay attention to the following safety aspects:
a. Avoid inhalation, contact with skin, and ingestion of compounds.
B. Use should wear experimental gloves, experimental glasses and protective clothing.
c. Should be operated in a well ventilated place.
d. In case of skin contact, rinse immediately with plenty of water and seek medical help.
e. In case of accidental inhalation or ingestion, seek medical attention immediately.
f. The compound should be stored in a dry, cool, well-ventilated place, avoiding contact with oxygen, heat, and fire.
Last Update：2024-04-09 21:21:28
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View History
Tert-butyl 5-Bromopyridin-2-ylcarbamate
Benzenepropanoic acid, α-acetyl-4-chloro-α-2-propen-1-yl-, ethyl ester
112899-25-9
Bis[3-[(2-henicosyloxycarbonylphenyl)carbonyloxy]propane-1-sulfonic acid]calcium salt
4-Pyridylisopropoxycarbonyl-hydrazid
Behenic acid [(2-henicosyl-4,5-dihydro-4-(hydroxymethyl)oxazol)-4-yl]methyl ester
Benzenepropanoic acid, α-acetyl-4-chloro-α-2-propen-1-yl-, ethyl ester
112899-25-9
Bis[3-[(2-henicosyloxycarbonylphenyl)carbonyloxy]propane-1-sulfonic acid]calcium salt
4-Pyridylisopropoxycarbonyl-hydrazid
Behenic acid [(2-henicosyl-4,5-dihydro-4-(hydroxymethyl)oxazol)-4-yl]methyl ester