TAS 103
TAS-103 (dihydrochloride)
CAS: 174634-09-4
Molecular Formula: C20H21Cl2N3O2
TAS 103 - Names and Identifiers
TAS 103 - Physico-chemical Properties
| Molecular Formula | C20H21Cl2N3O2 |
| Molar Mass | 406.30564 |
| Solubility | H2O: 15.3 mg/mL |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC 50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC 50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation. |
| In vivo study | TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103. |
TAS 103 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.461 ml | 12.306 ml | 24.612 ml |
| 5 mM | 0.492 ml | 2.461 ml | 4.922 ml |
| 10 mM | 0.246 ml | 1.231 ml | 2.461 ml |
| 5 mM | 0.049 ml | 0.246 ml | 0.492 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: BMS-247615 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 174634-09-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: TAS-103 (dihydrochloride) Visit Supplier Webpage Request for quotationCAS: 174634-09-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: TAS-103 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 174634-09-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: TAS-103 (dihydrochloride) Visit Supplier Webpage Request for quotation
CAS: 174634-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 174634-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: BMS-247615 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 174634-09-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: TAS-103 (dihydrochloride) Visit Supplier Webpage Request for quotationCAS: 174634-09-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: TAS-103 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 174634-09-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: TAS-103 (dihydrochloride) Visit Supplier Webpage Request for quotation
CAS: 174634-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 174634-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
TAS 103
Cyclobutanecarboxaldehyde, 2-[(1R)-1-methoxyethyl]-, (1S,2S)-rel-
十八碳-9-烯酸甲酯
ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Piperidine, 3-[4-(methylthio)phenyl]-
20(S)-Hydroxy Prednisolone-d4
ACTH (4-7)
ETHYL N-(2-[2-(3-CHLOROPHENYL)HYDRAZONO]-2-CYANOACETYL)CARBAMATE
2-(methylthio)pyridin-3-amine hydrochloride
2-{[(1-ethylpyrrolidin-2-yl)methyl]amino}-N-(3-methoxypropyl)propanamide
Cyclobutanecarboxaldehyde, 2-[(1R)-1-methoxyethyl]-, (1S,2S)-rel-
十八碳-9-烯酸甲酯
ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Piperidine, 3-[4-(methylthio)phenyl]-
20(S)-Hydroxy Prednisolone-d4
ACTH (4-7)
ETHYL N-(2-[2-(3-CHLOROPHENYL)HYDRAZONO]-2-CYANOACETYL)CARBAMATE
2-(methylthio)pyridin-3-amine hydrochloride
2-{[(1-ethylpyrrolidin-2-yl)methyl]amino}-N-(3-methoxypropyl)propanamide