Name | Sorbitol |
Synonyms | Gulitol Esasorb Sorbite Sorbitol D-Sorbit Glucitol Clucitol L-gulitol D-Glucitol D-Sorbitol Glucitol, D- Liponic 70-NC Karion, sionit Hexahydric alcohol Hydex 100 gran.206 |
CAS | 50-70-4 98201-93-5 |
EINECS | 200-061-5 |
InChI | InChI=1/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1 |
InChIKey | FBPFZTCFMRRESA-JGWLITMVSA-N |
Molecular Formula | C6H14O6 |
Molar Mass | 182.17 |
Density | 1.28g/mLat 25°C |
Melting Point | 98-100 °C (lit.) |
Boling Point | bp760 105° |
Specific Rotation(α) | 4 º (per eur. pharm.) |
Flash Point | >100°C |
Water Solubility | SOLUBLE |
Solubility | Soluble in water (235g/100g water, 25°C), glycerin, propylene glycol, slightly soluble in methanol, ethanol, acetic acid, phenol and acetamide solutions. Almost insoluble in most other organic solvents. |
Vapor Presure | <0.1 mm Hg ( 25 °C) |
Vapor Density | <1 (vs air) |
Appearance | White crystalline powder |
Specific Gravity | 1.28 |
Color | White |
Odor | Odorless |
Maximum wavelength(λmax) | ['λ: 260 nm Amax: 0.04', , 'λ: 280 nm Amax: 0.045'] |
Merck | 14,8725 |
BRN | 1721899 |
pKa | pKa (17.5°): 13.6 |
PH | 5.0-7.0 (25℃, 1M in H2O) |
Storage Condition | room temp |
Stability | Stable. Avoid strong oxidizing agents. Protect from moisture. |
Sensitive | Hygroscopic |
Refractive Index | n20/D 1.46 |
MDL | MFCD00004708 |
Physical and Chemical Properties | Character white odorless crystalline powder, sweet, hygroscopic. melting point 97 ℃ relative density 1.489 refractive index 1.3477(10% aqueous solution) solubility in water (235g/g water, 25 ℃), glycerin, propylene glycol, slightly soluble in methanol, ethanol, acetic acid, phenol and acetamide solution. Almost insoluble in most other organic solvents. |
Use | Used as an intermediate for vitamin C |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S8 - Keep container dry. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 2 |
RTECS | LZ4290000 |
FLUKA BRAND F CODES | 3 |
TSCA | Yes |
HS Code | 29054491 |
Toxicity | LD50 orally in Rabbit: 15900 mg/kg |
Reference Show more | 1. Tian Lei, Li Enyuan, Guan Tongwei, Tang Shukun, Liu Xiaofei, Zhang Xiaoping. Diversity and screening of functional enzymes and antibacterial activity of culturable halophilic bacteria in Aiding Lake [J]. Microbiology, 2017,44(11):2575-2587. 2. Niepexian, Wang Laiping, Han Xuepin, Lu Chao, Xue Xiaomin. Cloning of sorbitol dehydrogenase gene and its expression and enzyme activity during fruit development in apricot [J]. Journal of Nuclear-Agricultural Sciences, 2021,35(02):291-297. 3. Xue Xiaomin, Han Xuepin, Wang Jinzheng, Dong Fang. Analysis of sugar and acid components in plum fruit at different harvest time [J]. Jiangsu Agricultural Sciences, 2020,48(21):220-224. 4. Dong Li, raiting Xue. Effect of high temperature and high humidity gas impact treatment on quality of mid-short wave infrared dried jujube [J]. Food Research and Development, 2020,41(22):107-112. 5. [IF = 2.19] Li-Ping Zhang et al.. "J Food Process Pres. 2014 Aug;38(4):1749-1758 6. [IF = 7.053] Y.T. Xu et al." Ultra efficient stabilization of high internal phase simulations by globular proteins in the presence of polyols: Importance of a core-shell nanostructure."Food Hydrocolloid. 2020 Oct;107:105968 7. [IF=5.537] Chen Huan et al."Transcriptome analysis reveals the metabolisms of starch degradation and ethanol fermentation involved in alcoholic off-flavour development in kiwifruit during ambient storage."Postharvest Biol Tec. 2021 Oct;180:111621 8. [IF=3.638] Chen Huan et al."Effect of benzothiadiazole treatment on quality and anthocyanin biosynthesis in plum fruit during storage at ambient temperature."J Sci Food Agr. 2021 Jun;101(8):3176-3185 9. [IF=4.24] Haonan Shi et al.Effect of cryoprotectants on the formation of advanced glycation end products and acrylamide in fried fish cakes.Food Biosci. 2021 Dec;44:101433 |
White needle-like crystalline powder, odorless, cool and sweet, sweetness of sucrose 50% ~ 70%. It has the characteristics of high moisture absorption, soluble in water and hot ethanol, heat resistance and the like, and is not easy to react with amino acids, proteins and the like. The sorbitol solution is a clear colorless syrup-like liquid, and is a 68% to 76% sorbitol aqueous solution.
The refined glucose obtained by saccharification of starch is obtained by continuous or batch hydrogenation under medium pressure.
This product is D-sorbitol, calculated as dry product, containing C6H14O6 not less than 98.0%.
take about 5g of this product, accurately weigh it, put it in a 50ml measuring flask, add 6.4g of borax and an appropriate amount of water, shake it to completely dissolve it, and dilute it to the scale (if the solution is not clear, should be filtered), according to the law (General 0621), specific rotation of 4.0 ° to 7.0 °.
nutritive sweeteners, humectants, chelating agents and stabilizers. It is a special sweetener with moisturizing function. In the human body does not convert to glucose, not controlled by insulin, suitable for use by people with diabetes. Can be used for cakes, the maximum use of 5. Og/kg; In surimi and its products in the maximum use of 0. 5g/kg. It can also be used as a defoaming agent for sugar making process, brewing process and bean products process, according to the production needs of appropriate use. It can also be used for the moisturizing of currants, the thickening of alcohol, cool drinks, and sweet candy and chewing gum.
Take 5.0g of this product, add 50ml of New boiling and cooling water to dissolve, add 3 drops of phenolphthalein indicator solution and 0.02 ml of sodium hydroxide titration solution (0.30 mol/L), which should be light red.
take 3.0g of this product and add 20ml of water to dissolve. The solution should be clear and colorless.
take 0801g of this product and check it according to law (General rule 0.005%). Compared with the control solution made of standard gasification sodium solution, it should not be more concentrated ().
take 2.0g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.01% of standard potassium sulfate solution, it should not be more concentrated ().
take 10.OG of this product, put it in a 400ml beaker, add 35ml of water to dissolve, add 50ml of Alkaline copper tartrate test solution, cover the glass dish, heat to boil within 4-6 minutes, and continue boiling for 2 minutes, immediately add ml of fresh boiling and cold water, filter through a vertical melting glass crucible of constant weight at 105°C, wash the container and the precipitate with 30ml of hot water in portions, and then wash the precipitate with 10ml of ethanol and ether successively, drying at 105°C to constant weight resulted in a cuprous oxide weight of no more than 67mg.
take 2.lg of this product, put it in a 250ml grinding mouth flask, add about 40ml of hydrochloric acid solution (9-1000), heat and reflux for 4 hours, let it cool, move the hydrochloric acid solution into a 400ml beaker, the container was washed with 10ml of water and placed in a beaker, neutralized with 24% sodium hydroxide solution, and operated according to law under the item of reducing sugar from "adding 50ml of basic copper tartrate test solution". The weight of the obtained cuprous oxide should not exceed 50mg.
take about 0.5g of this product, put it in a 10ml measuring flask, add water to dissolve and dilute to the scale, shake well, and use it as a test solution; Take 2ml for precision measurement, put it in a ml measuring flask, as a control solution, it was diluted to the scale with water and shaken. About 0.5g of mannitol control and g of sorbitol control, respectively, were placed in a 10ml measuring flask, dissolved with water and diluted to the scale, and then shaken, as a system applicable solution. According to the high performance liquid chromatography (General 0512) test, a strong cation calcium type exchange column (or a column with equivalent separation efficiency) with the sulfonated crosslinked styrene divinylbenzene copolymer as the filler; Water as the mobile phase; the flow rate was 0.5ml per minute, the column temperature was 72-85°C, and the refractive index detector was used. Take the system applicable solution 20u1 injection human liquid chromatography, mannitol peak and sorbitol peak separation degree should be greater than 2.0. The 20u1 of the control solution and the test solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (2.0%), and the sum of each impurity peak area shall not be greater than 1.5 times (3.0%) of the area of the main peak of the control solution..
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure at 60°C to a constant weight, and the weight loss shall not exceed 1.0% (General rule 0831).
not more than 0.1% (General rule 0841).
Take 2.G of this product, add 2ml of acetate buffer (pH 3.5) and an appropriate amount of water to dissolve it into 25ml, and check it according to law (General rule 0821 first method). The heavy metal content shall not exceed 10 parts per million.
take this product l.O g, Add 10ml of water to dissolve, add 5ml of dilute sulfuric acid and 0.5ml of potassium bromide bromide solution, and heat on a water bath for 20 minutes to keep a slight excess of bromine present (if necessary, potassium bromide and bromine solution can be added dropwise), and at any time to replace the evaporation of water, cool, add hydrochloric acid 5ml and water appropriate amount to make 28ml, according to law inspection (General Principles 0822 The first law), the provisions (0.0002%) shall be met.
take about 0.2g of this product, accurately weigh, put it in a 250ml measuring flask, add water to dissolve and dilute to the scale, shake well; Take 10ml of precision, put it in an iodine bottle, precision add sodium (potassium) periodate solution [take sulfuric acid solution (1-20)90ml and sodium (potassium) periodate solution (2.3-1000)110ml, mix to make] 50ml, put on water bath heating for 15 minutes, cold, add potassium iodide solution 10ml, plug, place for 5 minutes, with sodium thiosulfate titration solution (0.05mol/L) titration, near the end point, add starch indicator solution lml, titration was continued until the blue color disappeared and the results of the titration were corrected with a blank test. Each 1 ml of sodium thiosulfate titration solution (0.05mol/L) corresponds to 0.9109mg of C6H14O6.
dehydration drugs.
light shielding, sealed storage.
This product is a sterilized aqueous solution of sorbitol. Sorbitol (C6H1406) should be 95.0% to 105.0% of the label amount.
This product is a clear colorless liquid.
take 10ml of this product with precision (about 2.5g of sorbitol), put it in a 100ml measuring flask, dilute it with water to scale, and shake it well; Take 10ml with precision, put it in a 250ml measuring flask, dilute with water to the scale, shake, according to the method under the sorbitol content determination item, from the "precision take 10ml, put in the iodine bottle", according to the law. Each 1 ml of sodium thiosulfate titration solution (0.05mol/L) corresponds to 0.9109mg of C6H14O6.
with sorbitol.
(l)lOOml:25g (2)250ml:62.5g
light shielding, closed storage.