STEVENLEAF 绞股蓝皂苷(混合物) 标准品
Gypenosides
CAS:
Molecular Formula: 混合物
STEVENLEAF 绞股蓝皂苷(混合物) 标准品 - Names and Identifiers
STEVENLEAF 绞股蓝皂苷(混合物) 标准品 - Physico-chemical Properties
| Molecular Formula | 混合物 |
| Solubility | Easily soluble in water and hot ethanol. Insoluble in ethyl/ether and benzene |
| Appearance | White powder |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
STEVENLEAF 绞股蓝皂苷(混合物) 标准品 - Reference
| Reference Show more | 1. Cai Yu, Zhou Hongli, Duan Wentao, et al. Effects of gypenosides on oxidative stress and hepatocyte apoptosis in rats with nonalcoholic fatty liver disease [J]. Chinese Journal of Clinical Pharmacology, 2020, 036(014):1256-1259. 2. Lin Yanping, Huang Jiachun, Chen Tongying, etc. Mechanism of gypenosides attenuating oxidative stress injury of rat osteoblasts induced by H2O2 [J]. Chinese Journal of Tissue Engineering Research, 2020. 3. Chen Minyan, Yang Gang, Wu Feihua, etc. Preparation and in vitro evaluation of gypenosides loaded nanostructured lipid carriers [J]. Pharmaceutical Care and Research, 2020(1). 4. He, Min, et al. "Inhibitory effects of glyproosides on seven human cytochrome P450 enzymes in vitro." Food and chemical Biology 57 (2013): 262-265.https:// doi.org/10.1016/j. FCT. 3/3/041 5. [IF=6.023] Min He et al."Inhibitory effects of gypenosides on seven human cytochrome P450 enzymes in vitro."Food Chem Toxicol. 2013 Jul;57:262 6. [IF=2.998] Su Jianhui et al."Hypolipidemic mechanism of gypenosides via inhibition of pancreatic lipase and reduction in cholesterol micellar solubility."Eur Food Res Technol. 2016 Mar;242(3):305-312 7. [IF=6.4] Gang Yang et al."Formulation design, characterization and in vitro and in vivo evaluation of nanostructured lipid carriers containing a bile salt for oral delivery of gypenosides."Int J Nanomed. 2019; 14: 2267-2280 |
STEVENLEAF 绞股蓝皂苷(混合物) 标准品 - Reference Information
| Overview | manual for the extraction and separation of chemical constituents of natural medicines Gynostemma pentaphyllum(Thunb.) makino.) it is a perennial herbaceous Vine of Gynostemma, Cucurbitaceae, and is the only plant known to contain ginsenosides in the genus Panax of non-Araliaceae, known as "Southern ginseng. Gynostemma pentaphyllum has a moderate and humid climate, which is widely distributed in Southeast Asia and other places, as well as in China's Qinling Mountains and regions south of the Yangtze River. According to statistics, so far the world's Gynostemma pentaphyllum total of 17 species and 2 varieties. Gynostemma pentaphyllum saponin (Gyp) is one of the most important functional components in Gynostemma pentaphyllum, and has attracted much attention due to its similar basic structure of tetracyclic triterpene damarane. Due to the thermal instability of Dammarane saponin itself, it is easy to be hydrolyzed in the process of heating extraction. Therefore, in recent years, there are new reports of gypenosides. There are 165 gypenosides that have been identified so far, there are 12 kinds of aglycones. Gynostemma pentaphyllum glycoside A: molecular formula C54H88O21, molecular weight 1072. White powder solid, mp.272 ℃ ~ 274 ℃, foam test was positive, Liebermann-Burehard reaction was yellow-brown, Molish reaction was brown-yellow. |
| uses | studies have shown that gypenosides has the advantages of anti-aging, anti-tumor, hypoglycemic, hypolipidemic, protect the liver and nerve and other aspects of biological activity, and its pharmacological activity is closely related to its side chain sugar, General gypenosides side chain sugar molecules the less the higher the activity. The latest metabonomics and pharmacology research found that the main components of gypenosides, which play a pharmacological role in the body, are Gynostemma pentaphyllum saponin monomers or secondary aglycones that do not exist in Gynostemma pentaphyllum, since gypenosides and ginsenosides have the same aglycone skeleton structure, part of gypenosides can be converted into rare ginsenosides in vivo. |
| classification | studies so far have found that gypenosides mostly have the basic structure of Dammarane type, it is mainly composed of tetracyclic triterpene Dammarane type saponin aglycone and glycosyl. The absolute configuration of its C20 upper chiral center is divided into R-configuration and S-configuration, in which gypenosides Gyp-XXXIX, Gyp-XL, Gyp-XLI, Gyp-LI, Gyp-LIII are R-configuration, the rest are in the S-configuration. With the deepening of research, more and more new gypenosides have been found. Therefore, in order to carry out better research, it is particularly important to classify gypenosides systematically. The academic circle mainly classifies Gynostemma pentaphyllum saponin aglycones according to their structural similarity. In 2011, on the basis of previous studies, the types of aglycones with conjugated double bonds at 23, 24 and 25, 26 of the side chains were supplemented, the identified 165 gypenosides were classified into 12 classes according to the degree of structural similarity of aglycones. Among them, gypenosides damarene double bond in the 24, 25 most, there are 102; Side chain 21,23 with epoxy structure of 13; Side chain 23, the 24-position has a double bond and the side chain has 9 kinds of each of 21-carboxylic acid and 21,23-lactone structures. |
| Application | Gynostemma pentaphyllum saponin can treat and prevent hypertension and other cardiovascular diseases, diabetes, constipation, hemorrhoids, asthma, migraine, acne, mottling and other symptoms have a significant effect, and have a more obvious sedative, hypnotic, eliminate fatigue, increase appetite, anti-aging effect, the tumor, hepatitis, gastritis, gastric and duodenal ulcer, gastroptosis, stomatitis, coronary heart disease, arteriosclerosis, gallstones, limb numbness, rough skin, male infertility, sexual function decline, obesity and white hair Baldness have better curative effect. Used for lowering blood pressure, lowering blood fat, treating constipation and nourishing the mind to improve immunity, enhance physical strength, reduce or eliminate weakness, fatigue symptoms, delay aging, improve mental activity, improve brain function; it can also be used to maintain the health of the heart and brain blood vessels, and to inhibit the formation of thrombosis. Sedative, hypnotic |
Last Update：2024-04-09 15:16:55
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Product Name: Gypenosides Visit Supplier Webpage Request for quotationTel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Gypenoside Visit Supplier Webpage Request for quotationTel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
Wechat: +86 13875855783
WhatsApp: +86 18374838656
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STEVENLEAF 绞股蓝皂苷(混合物) 标准品
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2-氨基-7-氮杂螺[3.5]壬烷-7-羧酸叔丁酯
2-[(2,2-二甲基-4-氧代-3,4-二氢-2H-7-色满基)氧基]乙腈
(S)-(+)-2-二苄基氨基-3-苯基-1-丙醇
(4,4'-二甲氧基-2,2'-联吡啶-ΚN1,ΚN1')双[3,5-二氟-2-(5-甲基-2-吡啶基-ΚN)苯基-ΚC]铱 六氟磷酸盐