Molecular Formula | C20H27N3O6 |
Molar Mass | 405.44488 |
Melting Point | 214-216℃ |
Specific Rotation(α) | D20 -64.1° (c = 0.5 in ethanol) |
Solubility | H2O: ≥5mg/mL |
Appearance | powder |
Color | white to tan |
Merck | 14,4911 |
Storage Condition | -20°C |
In vitro study | As a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
WGK Germany | 3 |
RTECS | NI8927400 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.263 ml | 11.315 ml | 22.629 ml |
5 mM | 0.453 ml | 2.263 ml | 4.526 ml |
10 mM | 0.226 ml | 1.131 ml | 2.263 ml |
5 mM | 0.045 ml | 0.226 ml | 0.453 ml |