Name | SC-560 |
Synonyms | SC-560 SC-560 SC-560 5-(4-Chlorophenyl) SC-560 Assay Reagent 5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-TRIFLUOROMETHYLPYRAZOLE 5-(4-Chlorophenyl)-3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazole 5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 1H-Pyrazole, 5-(4-chlorophenyl)-1-(4-Methoxyphenyl)-3-(trifluoroMethyl)- |
CAS | 188817-13-2 |
InChI | InChI=1/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3 |
Molecular Formula | C17H12ClF3N2O |
Molar Mass | 352.74 |
Density | 1.33 |
Melting Point | 63 °C |
Boling Point | 440.6±45.0 °C(Predicted) |
Flash Point | 220.3°C |
Solubility | DMSO: >20mg/mL |
Vapor Presure | 1.51E-07mmHg at 25°C |
Appearance | Off-white solid |
Color | White to Light yellow to Light orange |
pKa | -3?+-.0.10(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.563 |
Physical and Chemical Properties | Storage Conditions: 2-8 ℃ WGK Germany:3 |
In vitro study | Preincubation of COX-1 with SC-560 inhibits the conversion of arachidonic acid to PGE2 in a concentration-dependent manner. The IC 50 of SC-560 for COX-2 is 6.3 μM, nearly 1,000-fold higher than with COX-1. SC-560 shows a dose and time dependent inhibitory effect on HCC cell growth. SC-560 also inhibits colony formation in soft agar and induces apoptosis in HCC cells in a dose-dependent manner. Moreover, SC-560 decreases the levels of the anti-apoptotic proteins survivin and XIAP and activates caspase 3 and 7 in a dose and time dependent fashion. |
In vivo study | Oral dosing with either 10 or 30 mg/kg SC-560 1 hour before assay completely inhibits ionophore-stimulated TxB2production, indicating that SC-560 is orally bioavailable and inhibits COX-1 in vivo . SC-560 extensively distributes into rat tissues, and has a CL approaching hepatic plasma flow. The drug displays low less than 15% and formulation dependent bioavailability after oral administration and demonstrates kidney toxicity. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.835 ml | 14.175 ml | 28.349 ml |
5 mM | 0.567 ml | 2.835 ml | 5.67 ml |
10 mM | 0.283 ml | 1.417 ml | 2.835 ml |
5 mM | 0.057 ml | 0.283 ml | 0.567 ml |
Biological activity | SC-560 is a highly selective COX-1 inhibitor with an IC50 value of 9 nM, and for COX-2 The IC50 value is 6.3 μM is nearly 1,000 times higher than COX-1. |
Target | Value |
COX-1 (Cell-free assay) | 9 nM |
COX-2 (Cell-free assay) | 6.3 μM |