SB 216763
SB216763
CAS: 280744-09-4
Molecular Formula: C19H12Cl2N2O2
SB 216763 - Names and Identifiers
SB 216763 - Physico-chemical Properties
| Molecular Formula | C19H12Cl2N2O2 |
| Molar Mass | 371.22 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Melting Point | 287-288.6°C(lit.) |
| Boling Point | 598.1±50.0 °C(Predicted) |
| Solubility | DMSO: 20mg/mL, soluble |
| Appearance | Orange solid |
| Color | orange |
| pKa | 7.27±0.60(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| MDL | MFCD09753369 |
| Use | SB 216763 |
| In vitro study | In addition to inhibiting GSK-3α,SB 216763 is also effective at GSK-3β, inhibiting up to 96% when treated at 10 μm, and has minimal activity when acting on 24 other protein kinases including pkbα and pdk1, IC50>10 μm. SB-216763 acts on human liver cells to stimulate glycogen synthesis with an EC50 of 3.6 μm, and acts on HEK293 cells to induce the transcription of β-catenin-Lef/TCF-related reporter genes in a dose-dependent manner, according to 5 M treatment, the induction reached the maximum value, increased by 2.5 times. Consistent with a significant dose-dependent inhibition of GSK-3 activity, SB 216763 protects cerebellar granule neurons from apoptosis induced by LY-294002 or potassium loss in a concentration-dependent manner, 3 M when the protective nerve reached the highest value, and 10 mM LiCl effect contrast. 3 μm SB 216763 completely inhibited LY-294002-induced death of chicken dorsal root ganglion sensory neurons. 5 μm SB 216763 in HEK293 cells significantly inhibited GSK-3-dependent phosphorylation of neuron-specific microtubule-associated proteins in cerebellar granule neurons and increased the cytoplasmic level of β-catenin, similar to the GSK-3 inhibitory effect of Wnt regulation. 25-50 μm SB 216763 acts on prostate cancer cell lines, including BXPC-3, MIA-PaCa2, PANC1, ASPC1, and CFPAC, reducing cell viability in a dose-dependent manner and significantly promoting apoptosis, apoptosis reached 50%, while there was no effect on HMEC or WI38 cell lines. |
| In vivo study | SB 216763 treated mice with Bleomycin (BLM)-induced lung inflammation and fibrosis at a dose of 20 mg/kg significantly inhibited the MCP-1 of inflammatory cytokines and the production of TNF-α, lung inflammation and fibrosis were significantly inhibited, and the lifespan of BLM-treated mice was significantly increased. SB 216763 treatment significantly reduced BLM-induced alveoli by inhibiting alveolar epithelial cell injury. |
SB 216763 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
SB 216763 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.694 ml | 13.469 ml | 26.938 ml |
| 5 mM | 0.539 ml | 2.694 ml | 5.388 ml |
| 10 mM | 0.269 ml | 1.347 ml | 2.694 ml |
| 5 mM | 0.054 ml | 0.269 ml | 0.539 ml |
Last Update：2024-01-02 23:10:35
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QQ: 3008007409
Featured ProductsSpot supply
Product Name: SB 216763 Visit Supplier Webpage Request for quotationCAS: 280744-09-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SB 216763 Visit Supplier Webpage Request for quotationCAS: 280744-09-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SB 216763 Visit Supplier Webpage Request for quotationCAS: 280744-09-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SB216763 Visit Supplier Webpage Request for quotationCAS: 280744-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
SB 216763
zincdioleate
130759-56-7
sexual pheromone of Cosmopolites sordidus Germar
3-bromopyridine-2-carbaldehyde
52882-14-1
N-[2-(1-pyrrolidinyl)-5-(1-pyrrolidinylcarbonyl)phenyl]acetamide
5-(5-ethyl-3-thienyl)-4-(1-phenylethyl)-4H-1,2,4-triazol-3-yl hydrosulfide
1071017-64-5
1795441-70-1
zincdioleate
130759-56-7
sexual pheromone of Cosmopolites sordidus Germar
3-bromopyridine-2-carbaldehyde
52882-14-1
N-[2-(1-pyrrolidinyl)-5-(1-pyrrolidinylcarbonyl)phenyl]acetamide
5-(5-ethyl-3-thienyl)-4-(1-phenylethyl)-4H-1,2,4-triazol-3-yl hydrosulfide
1071017-64-5
1795441-70-1