S-3-(4-乙酰氨基苯氧基)-2-羟基-2-甲基-N-(4-硝基-3-三氟甲基苯基)丙酰胺
Andarine
CAS:
Molecular Formula: C19H18F3N3O6
S-3-(4-乙酰氨基苯氧基)-2-羟基-2-甲基-N-(4-硝基-3-三氟甲基苯基)丙酰胺 - Names and Identifiers
S-3-(4-乙酰氨基苯氧基)-2-羟基-2-甲基-N-(4-硝基-3-三氟甲基苯基)丙酰胺 - Physico-chemical Properties
| Molecular Formula | C19H18F3N3O6 |
| Molar Mass | 441.36 |
| Density | 1.47 |
| Melting Point | 70-74℃ |
| Boling Point | 698.7±55.0 °C(Predicted) |
| Water Solubility | 1.2 mg/mL in water |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | neat |
| Color | Light Yellow |
| BRN | 9666695 |
| pKa | 12.13±0.29(Predicted) |
| Storage Condition | Refrigerator |
| In vitro study | In Vitro, Andarine binds with high affinity to the androgen receptor with a K I of 4 nM. Moreover, 10 nM Andarine stimulated androgen receptor-regulated transcription by 93%. |
| In vivo study | In Vivo, Andarine has potent anabolic activity and stimulates the growth of prostate, seminal vesicle, and levator ani muscle with ED50 of 0.43 mg/day and 0.55 mg/day, respectively, and 0.14 mg/day, the effect was dose-dependent. In addition, Andarine acted on FSH, did not affect some physiological changes caused by castration, and treated with 0.5 mg or more per day, partially inhibited LH production. Intravenous administration of 0.1, 1, 3, and 10 mg/kg Andarine to dogs, total body clearance (CL) from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady state volume of distribution (Vss) is 1.39 L/kg, and the Half-Life is 229 minutes. In addition, the oral bioavailability of Andarine at doses of 10 mg/kg, 1 mg/kg, and 0.1 mg/kg was 38%, 62%, and 91%, respectively. Andarine has tissue-selective pharmacological activity and treatment of intact rats at a concentration of 0.5 mg/day significantly reduced prostate weight to 79.4%. |
S-3-(4-乙酰氨基苯氧基)-2-羟基-2-甲基-N-(4-硝基-3-三氟甲基苯基)丙酰胺 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
S-3-(4-乙酰氨基苯氧基)-2-羟基-2-甲基-N-(4-硝基-3-三氟甲基苯基)丙酰胺 - Reference Information
| biological activity | Andarine is a selective non-steroidal androgen receptor (AR)(androgen receptor) agonist with Ki of 4 nM and tissue selectivity for anabolic organs. Phase 3. Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR)(androgen receptor) agonist with Ki of 4 nM and tissue selectivity for anabolic organs. Phase 3. |
| features | Andarine are non-steroid androgen receptor (AR) selective stimulants. |
| Target | Value |
| Androgen Receptor | 4 nM(Ki) |
Last Update：2024-04-09 19:05:07
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S-3-(4-乙酰氨基苯氧基)-2-羟基-2-甲基-N-(4-硝基-3-三氟甲基苯基)丙酰胺
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C.I.15530
(2-(4-((4-氟苄基)氨基甲酰基)-5-羟基-6-氧代-1,6-二氢嘧啶-2-基)丙-2-基)氨基甲酸叔丁酯
2-(4-甲基-1-哌嗪基)-5-硝基吡啶
全氟(4-甲基-2-戊烯酸)
2-乙氧基-6-{[((丙-2-基)氨基]甲基}苯酚