RS 17053 hydrochloride (RS-17053)
(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE
CAS: 169505-93-5
Molecular Formula: C24H30Cl2N2O2
RS 17053 hydrochloride (RS-17053) - Names and Identifiers
RS 17053 hydrochloride (RS-17053) - Physico-chemical Properties
| Molecular Formula | C24H30Cl2N2O2 |
| Molar Mass | 449.41 |
| Storage Condition | Store at RT |
| In vitro study | In several tissues from rat and cloned adrenoceptors, RS 17053 hydrochloride displays high affinity for the α1A-adrenoceptor (pK i and pA 2 estimates of 9.1-9.9) and a 30-100-fold selectivity over the α1 B and the α1 D-adrenoceptor subtypes (pK i and pA 2 estimates of 7.7-7.8). However, in isolated smooth muscle preparations from human LUT tissues, RS 17053 hydrochloride antagonizes responses to NE only at high concentrations. Estimates of affinity (pA 2 ) at α1-adrenoceptors mediating NE-induced contractions are 7.5 in prostatic periurethral longitudinal smooth muscle (compared with 8.6 for prazosin), 6.9 in anterior fibromuscular stroma (prazosin, 8.9), and 7.1 in bladder neck (prazosin, 8.5). |
| In vivo study | RS 17053 hydrochloride has a rapid onset of action, and a duration of action exceeding 60 min. RS 17053 hydrochloride pretreatment significantly alteres food intake [F(4, 132) 5 6.28, p , 0.0001]. 10 mg/kg RS-17053 significantly suppresses food intake. |
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Product Name: (N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE Visit Supplier Webpage Request for quotation
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CAS: 169505-93-5
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Tel: +86-18821248368
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Product Name: (N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE Visit Supplier Webpage Request for quotation
CAS: 169505-93-5
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CAS: 169505-93-5
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View History
RS 17053 hydrochloride (RS-17053)
METHYL 1-CYCLOPENTENE-1-CARBOXYLATE
HARMINE HYDROCHLORIDE
葡萄糖酸钙(源头工厂)
Spiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxylic acid, 1',2',5,7-tetrahydro-2'-oxo-
ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Piperidine, 3-[4-(methylthio)phenyl]-
20(S)-Hydroxy Prednisolone-d4
ACTH (4-7)
ETHYL N-(2-[2-(3-CHLOROPHENYL)HYDRAZONO]-2-CYANOACETYL)CARBAMATE
METHYL 1-CYCLOPENTENE-1-CARBOXYLATE
HARMINE HYDROCHLORIDE
葡萄糖酸钙(源头工厂)
Spiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxylic acid, 1',2',5,7-tetrahydro-2'-oxo-
ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Piperidine, 3-[4-(methylthio)phenyl]-
20(S)-Hydroxy Prednisolone-d4
ACTH (4-7)
ETHYL N-(2-[2-(3-CHLOROPHENYL)HYDRAZONO]-2-CYANOACETYL)CARBAMATE