PBTZ 169
BTZ043
CAS: 1161233-85-7
Molecular Formula: C17H16F3N3O5S
PBTZ 169 - Names and Identifiers
PBTZ 169 - Physico-chemical Properties
| Molecular Formula | C17H16F3N3O5S |
| Molar Mass | 431.39 |
| Density | 1.68 |
| Melting Point | 190-191°C |
| Solubility | DMSO: 13.3 mg/mL |
| Appearance | Solid |
| Color | White to Pale Yellow |
| Storage Condition | -20°C Freezer |
| In vitro study | The MIC of BTZ043 against M. tuberculosis H37Rv and Mycobacterium smegmatis are 1 ng/mL (2.3 nM) and 4 ng/mL (9.2 nM), respectively. The in vitro activity of BTZ043 against 30 Nocardia brasiliensis isolates is also tested. The MIC50 and MIC90 values for BTZ043 are 0.125 and 0.25 μg/mL. The MIC for N. carnea ATCC 6847 is 0.003μg/mL, for N. transvalensis ATCC 6865 is 0.003μg/mL, for N. brasiliensis NCTC10300 is 0.03 μg/mL, and for N. brasiliensis HUJEG-1 is 0.125μg/mL. The MIC value for M. tuberculosis H37Rv is 0.000976 μg/mL. The MIC value of BTZ-043 is >64 μg/mL for Escherichia coli ATCC 25922 and S. aureus ATCC 29213. |
| In vivo study | Four weeks of treatment with BTZ043 reduces the bacterial burden in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. Additional results suggest that BTZ043 efficacy is time-rather than dose-dependent. Acute (5 g/kg) and chronic (25 and 250 mg/kg) toxicology studies in uninfected mice show that, even at the highest dose tested, there are no adverse anatomical, behavioral, or physiological effects after one month. |
PBTZ 169 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.318 ml | 11.591 ml | 23.181 ml |
| 5 mM | 0.464 ml | 2.318 ml | 4.636 ml |
| 10 mM | 0.232 ml | 1.159 ml | 2.318 ml |
| 5 mM | 0.046 ml | 0.232 ml | 0.464 ml |
Last Update：2024-01-02 23:10:35
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Multiple SpecificationsSpot supply
Product Name: BTZ043 Visit Supplier Webpage Request for quotationCAS: 1161233-85-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BTZ043 Visit Supplier Webpage Request for quotationCAS: 1161233-85-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BTZ043 Visit Supplier Webpage Request for quotationCAS: 1161233-85-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: BTZ043 Visit Supplier Webpage Request for quotationCAS: 1161233-85-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
PBTZ 169
PKCzeta Pseudosubstrate Inhibitor
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2-Amino-4-(4-chlorophenyl)-4H-pyrano[3,2-h]quinoline-3-carboxylic acid ethyl ester
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959110-22-6
1,3-二甲氧基-4-溴苯
5-bromo-4-nitro-thiophene-2-carboxylic acid ethyl ester
4H-Anthra[1,2-b]pyran-4,7,12-trione, 11-hydroxy-5-methyl-2-[(1R)-1-methylpropyl]-
66611-26-5
PKCzeta Pseudosubstrate Inhibitor
344269-80-3
2-Amino-4-(4-chlorophenyl)-4H-pyrano[3,2-h]quinoline-3-carboxylic acid ethyl ester
98977-44-7
959110-22-6
1,3-二甲氧基-4-溴苯
5-bromo-4-nitro-thiophene-2-carboxylic acid ethyl ester
4H-Anthra[1,2-b]pyran-4,7,12-trione, 11-hydroxy-5-methyl-2-[(1R)-1-methylpropyl]-
66611-26-5