Otenabant (Hydrochloride)
CP-945598 HCl
CAS: 686347-12-6
Molecular Formula: C25H26Cl3N7O
Otenabant (Hydrochloride) - Names and Identifiers
Otenabant (Hydrochloride) - Physico-chemical Properties
| Molecular Formula | C25H26Cl3N7O |
| Molar Mass | 546.87924 |
| Melting Point | 275-276℃ (decomposition) |
| Solubility | DMSO 1 mg/mL heat Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | room temp |
| Use | A selective and high affinity CB1 antagonist. |
| In vitro study | CP-945598 HCl inhibits the CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate central nervous system penetration. CP-945598 HCl acts on the human CB2 receptor with a low affinity, K I of 7.6 μm. |
| In vivo study | After CP-55940 treatment with synthetic CB1 receptor agonists, the CP-945598 of HCl reverses four cannabinoid agonist-mediated behaviors (spontaneous activity, hypothermia, analgesia, and general rigidity). CP-945598 HCl treated rodent models of acute food intake with loss of appetite and increased energy expenditure and fat oxidation. CP-945598 treatment of rats, severe stimulation of energy expenditure, and decreased the respiratory quotient, indicating metabolic conversion to increased fat oxidation. CP-945598 treated diet-induced obese mice at a dose of 10 mg/kg, CP-945598 promoted 9% weight loss in a 10-day weight loss study. |
Otenabant (Hydrochloride) - Risk and Safety
| WGK Germany | 3 |
Otenabant (Hydrochloride) - Introduction
Otenabant (CP-945598) HCl is an effective, selective cannabinoid receptor CB1 antagonist with a Ki of 0.7 nM, which is 10,000 times more selective than acting on human CB2 receptors.
Last Update：2022-10-16 17:41:46
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Product Name: CP 945598 Hydrochloride Visit Supplier Webpage Request for quotationCAS: 686347-12-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
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Mobile: 609-228-6898
Spot supply
Product Name: CP-945598 HCl Visit Supplier Webpage Request for quotationCAS: 686347-12-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Product Name: CP-945598 HCl Visit Supplier Webpage Request for quotationCAS: 686347-12-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
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View History
Otenabant (Hydrochloride)
ETHYL 2-[2,4-DICHLORO-5-(([3-(4-NITROPHENOXY)-2-THIENYL]CARBONYL)AMINO)PHENOXY]ACETATE
N-(3-methoxyphenyl)-2-{[2-(4-methylphenyl)cyclopropyl]carbonyl}hydrazinecarbothioamide
Einecs 221-455-3
4-(4-N-BUTYLPHENYL)BENZOIC ACID
N-(5-CHLORO-2-PYRIMIDINYL)-2-THIOPHENECARBOXAMIDE
139432-69-2
4-Bromophenyl carbonochloridate
17626-02-7
74103-06-3
ETHYL 2-[2,4-DICHLORO-5-(([3-(4-NITROPHENOXY)-2-THIENYL]CARBONYL)AMINO)PHENOXY]ACETATE
N-(3-methoxyphenyl)-2-{[2-(4-methylphenyl)cyclopropyl]carbonyl}hydrazinecarbothioamide
Einecs 221-455-3
4-(4-N-BUTYLPHENYL)BENZOIC ACID
N-(5-CHLORO-2-PYRIMIDINYL)-2-THIOPHENECARBOXAMIDE
139432-69-2
4-Bromophenyl carbonochloridate
17626-02-7
74103-06-3