Name | Nomegestrol |
Synonyms | Nomegestrol Nomegestrel Nomegestrolum UNII-10F89177CO Nomegestrol [INN] NOMEGESTROL ACETATE MELEGESTROL ACETATE Nomegestrolum [Latin] 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione 17-Hydroxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione 19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- (17alpha)-17-acetyl-17-hydroxy-6-methylestra-4,6-dien-3-one 17ALPHA-ACETOXY-6ALPHA-METHYL-19-NOR-PREGN-4,6-DIEN-3,20-DIONE (8S,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,13-dimethyl-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one |
CAS | 58691-88-6 |
EINECS | 200-258-5 |
InChI | InChI=1/C21H28O3/c1-12-10-18-16(15-5-4-14(23)11-17(12)15)6-8-20(3)19(18)7-9-21(20,24)13(2)22/h10-11,15-16,18-19,24H,4-9H2,1-3H3/t15-,16-,18-,19+,20+,21+/m1/s1 |
Molecular Formula | C21H28O3 |
Molar Mass | 328.45 |
Density | 1.17±0.1 g/cm3(Predicted) |
Boling Point | 502.6±50.0 °C(Predicted) |
Flash Point | 271.8°C |
Vapor Presure | 3.32E-12mmHg at 25°C |
pKa | 12.99±0.60(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.573 |
In vitro study | Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a K d of 5.44 nM for rat uterine progesterone receptor. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity. |