N-Cbz-glutamic acid α-benzyl ester
Z-Glu-OBzl
CAS: 3705-42-8
Molecular Formula: C20H21NO6
N-Cbz-glutamic acid α-benzyl ester - Names and Identifiers
| Name | Z-Glu-OBzl |
| Synonyms | Z-Glu-OBzl Z-L-GLU-OBZL Z-GLUTAMIC ACID-OBZL CBZ-L-GLUTAMIC ACID 2-BENZYL ESTER Cbz-L-Glutamic acid 1-benzyl ester N-Cbz-glutamic acid α-benzyl ester Z-L-GLUTAMIC ACID ALPHA-BENZYL ESTER N-ALPHA-CBZ-L-GLUTAMIC ACID ALPHA-BENZYL ESTER N-BENZYLOXYCARBONYL-L-GLUTAMIC ACID ALPHA-BENZYL ESTER N-ALPHA-CARBOBENZOXY-L-GLUTAMIC ACID ALPHA-BENZYL ESTER N-ALPHA-BENZYLOXYCARBONYL-L-GLUTAMIC-ACID-ALPHA-BENZYL ESTER 5-(benzyloxy)-4-{[(benzyloxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name) (4S)-5-(benzyloxy)-4-{[(benzyloxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name) |
| CAS | 3705-42-8 |
| EINECS | 2017-001-1 |
| InChI | InChI=1/C20H21NO6/c22-18(23)12-11-17(19(24)26-13-15-7-3-1-4-8-15)21-20(25)27-14-16-9-5-2-6-10-16/h1-10,17H,11-14H2,(H,21,25)(H,22,23)/t17-/m0/s1 |
N-Cbz-glutamic acid α-benzyl ester - Physico-chemical Properties
| Molecular Formula | C20H21NO6 |
| Molar Mass | 371.38 |
| Density | 1.268±0.06 g/cm3(Predicted) |
| Melting Point | 92-93?C |
| Boling Point | 594.3±50.0 °C(Predicted) |
| Flash Point | 313.2°C |
| Water Solubility | Soluble in methanol, dimethyl sulfoxide. Slightly soluble in water. |
| Solubility | Soluble in Methanol |
| Vapor Presure | 5.72E-15mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White |
| pKa | 4.47±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.575 |
| MDL | MFCD00077013 |
N-Cbz-glutamic acid α-benzyl ester - Introduction
Z-Glu-OBzl(Z-Glu-OBzl) is an organic compound commonly used as a protecting group for amino acids. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Molecular formula: C17H17NO4
-Molecular weight: 303.32g/mol
-Appearance: White crystalline powder
-Melting Point: 84-85°C
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dimethylformamide
- Cbz protecting group can be removed by palladium hydride catalyst under acidic conditions
Use:
- Z-Glu-OBzl is a protecting group of glutamic acid (Glu), which can be used in the synthesis of amino acid derivatives, polypeptides and proteins.
-As a protecting group for amino acids in synthetic organic compounds, it can protect the amine group of glutamic acid, prevent it from being affected by non-specific reactions, and facilitate removal when needed.
Preparation Method:
-The preparation of Z-Glu-OBzl usually includes a multi-step process and involves a series of chemical reactions. One of the common methods is to first protect the carboxyl group of glutamic acid as t-butoxycarbonyl ester (Boc) and then protect the amino group as Cbz. Finally, the desired product Z-Glu-OBzl is formed by reaction with benzyl chloroformate.
Safety Information:
- Z-Glu-OBzl should be treated as irritating compounds and avoid direct contact with skin and eyes.
-When used in the laboratory, correct safety procedures must be followed, including wearing protective glasses, gloves and laboratory coats.
-Inhalation or ingestion of the compound should be avoided and fire and explosion prevention measures should be taken during storage.
-The compound should be placed in a well-ventilated environment during processing, and waste should be properly disposed of in accordance with local regulations.
Nature:
-Molecular formula: C17H17NO4
-Molecular weight: 303.32g/mol
-Appearance: White crystalline powder
-Melting Point: 84-85°C
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dimethylformamide
- Cbz protecting group can be removed by palladium hydride catalyst under acidic conditions
Use:
- Z-Glu-OBzl is a protecting group of glutamic acid (Glu), which can be used in the synthesis of amino acid derivatives, polypeptides and proteins.
-As a protecting group for amino acids in synthetic organic compounds, it can protect the amine group of glutamic acid, prevent it from being affected by non-specific reactions, and facilitate removal when needed.
Preparation Method:
-The preparation of Z-Glu-OBzl usually includes a multi-step process and involves a series of chemical reactions. One of the common methods is to first protect the carboxyl group of glutamic acid as t-butoxycarbonyl ester (Boc) and then protect the amino group as Cbz. Finally, the desired product Z-Glu-OBzl is formed by reaction with benzyl chloroformate.
Safety Information:
- Z-Glu-OBzl should be treated as irritating compounds and avoid direct contact with skin and eyes.
-When used in the laboratory, correct safety procedures must be followed, including wearing protective glasses, gloves and laboratory coats.
-Inhalation or ingestion of the compound should be avoided and fire and explosion prevention measures should be taken during storage.
-The compound should be placed in a well-ventilated environment during processing, and waste should be properly disposed of in accordance with local regulations.
Last Update：2024-04-10 22:29:15
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View History
N-Cbz-glutamic acid α-benzyl ester
2-Pyridinemethanamine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
methacrylicacidanhydride
3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine
434306-64-6
1084625-20-6
(E)-1,1,1-TRIFLUORO-4-(3-PYRIDINYLAMINO)-3-BUTEN-2-ONE
1-(4-bromobenzoyl)-3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole
331962-45-9
1-methyl-6-nitro-4(1H)-Cinnolinone
2-Pyridinemethanamine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
methacrylicacidanhydride
3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine
434306-64-6
1084625-20-6
(E)-1,1,1-TRIFLUORO-4-(3-PYRIDINYLAMINO)-3-BUTEN-2-ONE
1-(4-bromobenzoyl)-3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole
331962-45-9
1-methyl-6-nitro-4(1H)-Cinnolinone