N-(3-氰基-7-乙氧基-4-羟基喹啉-6-基)乙酰胺

N-(3-氰基-7-乙氧基-4-羟基喹啉-6-基)乙酰胺 - Names and Identifiers

Name	N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
Synonyms	Neratinib Impurity 18 Neratinib Intermediate4 N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl) 3-Cyano-7-ethoxy-4-hydroxy-6-N-acetylquinoline N-(3-Cyan-7-ethoxy-4-hydroxychinolin-6-yl)acetamid 3-Cyano-7-ethoxy-4-hydroxy-6-(acetylaMino)quinoline 3-Cyano-7-ethoxy-4-hydroxy-6-(acetylaMino)quinolone N-(3-cyano-7-ethoxy-4-oxo-1H-quinolin-6-yl)acetamide N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetaMide N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
CAS	848133-75-5
InChI	InChI=1/C14H13N3O3/c1-3-20-13-5-11-10(4-12(13)17-8(2)18)14(19)9(6-15)7-16-11/h4-5,7H,3H2,1-2H3,(H,16,19)(H,17,18)

N-(3-氰基-7-乙氧基-4-羟基喹啉-6-基)乙酰胺 - Physico-chemical Properties

Molecular Formula	C14H13N3O3
Molar Mass	271.27
Density	1.35±0.1 g/cm3(Predicted)
Melting Point	>250℃
Boling Point	552.1±50.0 °C(Predicted)
Flash Point	244.962°C
Vapor Presure	0mmHg at 25°C
pKa	0.84±0.50(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.61

N-(3-氰基-7-乙氧基-4-羟基喹啉-6-基)乙酰胺 - Introduction

N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide is an organic compound with the chemical formula C15H15N3O7.

Nature:
-Appearance: N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide is a white to pale yellow solid.
-Solubility: It is soluble in ethanol, dimethyl sulfoxide and dichloromethane, but has low solubility in water.

Use:
-Chemical reagent: N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide can be used as a chemical reagent for organic synthesis reactions.
-Drug intermediate: It can also be used as a drug intermediate for the synthesis of biologically active compounds.

Preparation Method:
The synthesis of N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide is complex and involves multiple steps. A common synthesis method is to carry out the synthesis reaction starting from quinoline as the starting material, and then gradually introduce cyano group, hydroxyl group, acetylamino group and ethoxy group through a multi-step reaction.

Safety Information:
Regarding the safety information of N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide, the toxicity and danger of this compound have not been reported in detail. In general, when performing experiments, you should wear appropriate personal protective equipment, such as laboratory gloves and protective glasses, to avoid direct contact with skin and eyes. At the same time, the relevant safety operation procedures should be observed during operation and storage to ensure personal safety and the safety of the experimental environment.

Last Update：2024-04-09 21:54:55