N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide - Names and Identifiers
Name | N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide
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Synonyms | N-(2,4-Difluoro-3-forMyl)-propane-1-sulfonaMide N-(2,4-Difluoro-3-formylphenyl)-1-propanesulfonamide N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide 1-Propanesulfonamide, N-(2,4-difluoro-3-formylphenyl)- Propane-1-sulfonic acid (2,4-difluoro-3-formylphenyl)amide Propane-1-sulfonic acid N-(2,4-difluoro-3-formylphenyl)amide N-(2,4-Difluoro-3-formylphenyl)-1-propanesulfonamide
Propane-1-sulfonic acid N-(2,4-difluoro-3-formylphenyl)amide
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CAS | 918523-58-7
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N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide - Physico-chemical Properties
Molecular Formula | C10H11F2NO3S
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Molar Mass | 263.26 |
Density | 1.438±0.06 g/cm3(Predicted) |
Boling Point | 350.3±52.0 °C(Predicted) |
pKa | 6.55±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Use | Intermediate |
N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide - Introduction
N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide(N-(2,4-difluoro-3-formylphenyl) propanesulfonamide) is an organic compound. It is a powdery solid that is chemically active. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White to light yellow powder
-Molecular formula: C10H10F2N2O3S
-Molecular weight: 292.26g/mol
-Melting point: about 169-173°C
-Solubility: Slightly soluble in water, soluble in organic solvents such as dimethyl sulfoxide, dichloromethane, etc.
Use:
- N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide is a commonly used organic synthesis intermediate. It can be used as an important raw material for the preparation of various drugs, pesticides and chemical reagents.
-In drug research, N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide is also used to prepare or synthesize biologically active compounds.
Method:
- N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide can be prepared by reacting 2,4-difluoro-3-nitrophenylacrylic acid methyl ester with sulfinamide. First, methyl 2,4-difluoro-3-nitrophenylacrylate is reacted with sulfinamide in an appropriate solvent with heating to give N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide. After the reaction, the product can be purified by crystallization or column chromatography.
Safety Information:
- N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide may be harmful. Safety and protective measures for chemicals should be observed during handling and use.
-Avoid direct contact with skin, eyes and respiratory tract. Wear appropriate protective equipment, such as gloves, glasses and protective masks.
-In case of accidental contact, immediately rinse the affected area with plenty of water and seek medical help.
- N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide should be stored in a dry and cool place, away from fire and fragile products, and ensure that the container is sealed to avoid contact with air and humidity.
Last Update:2024-04-09 21:01:54