Name | N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide |
Synonyms | VX-770 Ivacaftor VX 770, Ivacaftor Ivacaftor (VX-770) N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxaMide N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide 3-QuinolinecarboxaMide, N-[2,4-bis(1,1-diMethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo- N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide Ivacaftor (VX-770) |
CAS | 873054-44-5 |
InChI | InChI=1/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29) |
Molecular Formula | C24H28N2O3 |
Molar Mass | 392.49 |
Density | 1.187 |
Melting Point | 212-215°C |
Boling Point | 550.4±50.0 °C(Predicted) |
Flash Point | 286.7°C |
Solubility | DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
Vapor Presure | 1E-12mmHg at 25°C |
Appearance | Solid |
Color | White to Light Brown |
pKa | 11.08±0.23(Predicted) |
Storage Condition | Refrigerator |
Refractive Index | 1.605 |
Use | Ivacaftor (VX-770) is an enhancer of cystic fibrosis transmembrane conduction regulator (CFTR), which targets G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM respectively. |
In vitro study | Ivacaftor(10 μm) significantly increased forskolin-stimulated Cl in Fisher rat thyroid (FRT) cells expressing CFTR mutant G551D |
In vivo study | Ivacaftor acts on cystic fibrosis subjects aged 6 to 11 carrying the G551D mutation and has completed Phase III study. |
HS Code | 29333990 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.548 ml | 12.739 ml | 25.478 ml |
5 mM | 0.51 ml | 2.548 ml | 5.096 ml |
10 mM | 0.255 ml | 1.274 ml | 2.548 ml |
5 mM | 0.051 ml | 0.255 ml | 0.51 ml |