N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate
Rizatriptan Benzoate
CAS: 145202-66-0
Molecular Formula: C22H25N5O2
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Names and Identifiers
| Name | Rizatriptan Benzoate |
| Synonyms | MAXALT MK-462 MK-0462 Rizatrimptan Rizatriptan Benzoate RIZATRIPTAN BENZOATE Rizatrimptan Benzoate RIZATRIPTANE BENZOATE Acid Bixente triptans Rizatriptan monobenzoate N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H- N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOLE-3-ETHANAMINE, BENZOATE n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethylamine benzoate N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate |
| CAS | 145202-66-0 |
| EINECS | 604-465-6 |
| InChI | InChI=1/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3 |
| InChIKey | JPRXYLQNJJVCMZ-UHFFFAOYSA-N |
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Physico-chemical Properties
| Molecular Formula | C22H25N5O2 |
| Molar Mass | 391.47 |
| Density | 1.21g/cm3 |
| Melting Point | 178-180°C |
| Boling Point | 504.8°C at 760 mmHg |
| Flash Point | 259.1°C |
| Solubility | Soluble in water (58 mg/ml), DMSO (20 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C) |
| Vapor Presure | 2.58E-10mmHg at 25°C |
| Appearance | White to off-white crystalline powder |
| Color | white to beige |
| Merck | 14,8241 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.645 |
| MDL | MFCD00866224 |
| Physical and Chemical Properties | Melting point 178-180°C |
| Use | Suitable for the treatment of migraine |
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 61 - May cause harm to the unborn child |
| WGK Germany | 3 |
| HS Code | 2933995500 |
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Standard
Authoritative Data Verified Data
This product is 3-[2-(dimethylamino> ethyl]- 5-(lH-l, 2, 4-triazol-1-ylmethyl) indole benzoate. Calculated as dried product, the content of C15H19N5 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline or crystalline powder; Odorless.
- This product is dissolved in water or methanol, slightly soluble in ethanol, and slightly soluble in ethyl acetate.
melting point
The melting point of this product (General 0612) is 179~183°C.
Last Update：2022-01-01 13:33:49
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Differential diagnosis
Authoritative Data Verified Data
- take this product, add water to dissolve and dilute it into a solution containing about 30ug per 1 ml, and measure it by UV-Vis spectrophotometry (General 0401), there is a maximum absorption at a wavelength of 280nm and a minimum absorption at a wavelength of 252nm.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
- identification reaction of benzoic acid salt (General rule 0301).
Last Update：2022-01-01 13:33:50
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Exam
Authoritative Data Verified Data
pH
take this product, add water to make a solution containing about 10 mg per lml, and determine it according to law (General 0631). The pH value should be 5.5~7.5.
chloride
take 0.25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.02% of standard sodium chloride solution, it should not be more concentrated ().
sulfate
take 0.5g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.05% of standard potassium sulfate solution, it should not be more concentrated ().
Related substances
take this product, add the mobile phase to dissolve and dilute to make a solution containing about 1.2mg per 1 ml, as a test solution; Take the appropriate amount of precision, A solution containing 12ug per 1 ml was prepared as a control solution by dilution with the mobile phase. According to the high performance liquid chromatography (General rule 0512) test, with eighteen alkyl silane bonded silica gel as filler, heptanesulfonic acid sodium solution (heptanesulfonate 1.04g, add water 1000ml to dissolve, add phosphoric acid 3ml, glacial acetic acid 3ml, using triethylamine to adjust the pH value to 3.0) -acetonitrile (80:20) as mobile phase, the detection wavelength was 280nm; The peak order was rizatriptan and benzoic acid, the number of theoretical plates shall not be less than 2500 based on rizatriptan peak. 2 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 4 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.1 times (0.1%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 0.3 times (0.3%) of the main peak area of the control solution.
residual solvent
take this product, precision weighing, add N ,N-dimethylformamide to dissolve and dilute to make a solution containing about 10 mg per 1 ml, as a test solution; Take methanol, dichloromethane, an appropriate amount of pyridine and toluene is accurately weighed and diluted quantitatively with N ,N-dimethylformamide to prepare a mixed solution containing about 30ug, 6ug, 2ug and 8.9ug per 1 ml as a reference solution. According to the determination method of residual solvent (General Principle 0861 third method), the capillary column with 5% diphenyl-95% dimethyl polysiloxane (or similar polar) as stationary liquid is used as the column; The temperature is programmed, and the initial temperature is 40°C, the temperature was maintained for 2 minutes at a rate of 10°C per minute to 220°C for 2 minutes; The inlet temperature was 180°C; And the detector temperature was 300°C. Take the reference solution into the sample, the separation degree between the peaks of each component should meet the requirements. The lul of the test solution and the reference solution were accurately measured and injected into the human gas chromatograph respectively, and the chromatogram was recorded. According to the external standard method to calculate the peak area, methanol, dichloromethane, pyridine and toluene residues should be in accordance with the provisions.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take 1.0g of this product and check it according to law (General rule 0841). The remaining residue shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 13:33:51
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add glacial acetic acid 40ml and acetic anhydride 5ml dissolved, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the titration results were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/ L) corresponds to 19.57mg of C15H19N5. C7H602.
Last Update：2022-01-01 13:33:51
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Category
Authoritative Data Verified Data
anti-migraine drugs.
Last Update：2022-01-01 13:33:52
N,N-dimethy1-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:33:52
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