Name | L-Phenylalanine |
Synonyms | PHE H-Phe-OH H-L-PHE-OH Phenylalanine L-Phenylalanie L-Phenylalanin L-Phenylalanine Phenyalanine, L- Phenylalanine, L- L-Alanine, phenyl- L(-)Phenylalaniline L-Antibiotic FN 1636 L-beta-Phenylalanine (S)-(-)-Phenylalanine l-beta-phenyl-alpha-alanin L-AminobenzenepropanoicAcid L-α-Amino-β-phenyl-propionsαure (S)-2-Amino-3-Phenylpropionic acid (S)-(-)-PHENYLALANINE FOR SYNTHESIS (S)-2-Amino-3-phenylpropionic acid~H-Phe-OH |
CAS | 63-91-2 3617-44-5 |
EINECS | 200-568-1 |
InChI | InChI:1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12) |
InChIKey | COLNVLDHVKWLRT-QMMMGPOBSA-N |
Molecular Formula | C9H11NO2 |
Molar Mass | 165.19 |
Density | 1.29 |
Melting Point | 270-275°C (dec.)(lit.) |
Boling Point | 293.03°C (rough estimate) |
Specific Rotation(α) | -34.1 º (c=2, water, dry basis) |
Flash Point | 153.1°C |
JECFA Number | 1428 |
Water Solubility | 1-5 g/100 mL at 25 ºC |
Solubility | Solubility in water (g/L):27g/L (20°C); Very slightly soluble in ethanol and methanol, hardly soluble in ether |
Vapor Presure | <1 Pa (25 °C) |
Appearance | White crystalline powder |
Color | White to off-white |
Merck | 14,7271 |
BRN | 1910408 |
pKa | 2.2(at 25℃) |
PH | 5.0-7.0 (25℃, 0.1M in H2O) |
Storage Condition | Store below +30°C. |
Stability | Stable. Incompatible with strong oxidizing agents. |
Sensitive | Sensitive to light |
Refractive Index | -34 ° (C=2, H2O) |
MDL | MFCD00064227 |
Physical and Chemical Properties | Solubility: H2O: 0.1 M at 20 ℃, clear, colorless WGK Germany:3 RTECS:AY7535000 |
Hazard Symbols | C - Corrosive |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | AY7535000 |
FLUKA BRAND F CODES | 10 |
TSCA | Yes |
HS Code | 29224995 |
White monoflaky, lobular or needle-like crystals. 283 degrees C decomposition. Very slightly soluble in ethanol, methanol.
after the defatted soybean was hydrolyzed with hydrochloric acid, acidic amino acids were removed, and phenylalanine and tyrosine were adsorbed with activated carbon or decolorizing resin. The phenylalanine may be dissolved and separated with a solvent.
This product is L-2-amino -3-phenyl propionic acid. Calculated as dried product, the content of C9H1N02 shall not be less than 98.5%.
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 20mg per lml, and determine according to law (General 0621), the specific rotation was -33.0 ° to -35.0 °.
for biochemical studies, medium preparation.
take 0.20g of this product, add 20ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 5.4~6.0.
take 0.50g of this product and add 25ml of water to dissolve it. According to ultraviolet-visible spectrophotometry (General rule 0401), determine the transmittance at 430nm wavelength, which shall not be less than 98.0%.
take 0.30g of this product and check it according to law (General rule 0801). Compared with the control solution made of 6.0 ml of standard sodium chloride solution, it should not be more concentrated (0.02%).
take 0.70g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.02% of standard potassium sulfate solution, it should not be more concentrated ().
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 2.0 ml of standard ammonium chloride solution, it shall not be deeper (0.02%).
take an appropriate amount of this product, add glacial acetic acid solution (50-100) to dissolve and dilute to make a solution containing about 10 mg per lml as a test solution; Take lml for precision measurement, add appropriate amount of phenylalanine reference substance and tyrosine reference substance to the same measuring flask, and add appropriate amount of glacial acetic acid solution (50-100) to dissolve, dilute with water to make about 10 mg phenylalanine and tyrosine per 1 ml. A solution of 1 mg, as a system-suitable solution. According to the thin layer chromatography (General 0502) test, draw 5ul of each of the above three solutions, respectively, on the same silica gel G thin layer plate, with n-butanol-glacial acetic acid-water (6:2:2) to develop, spread, dry, spray with ninhydrin in acetone solution (1-50), heat at 90°C until spots appear, and immediately inspect. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
take l.Og of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
take 2.0g of this product, add 23ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
take this product, add human endotoxin test water, heat it in a warm water bath to dissolve it, check it according to law (General rule 1143), and the amount of endotoxin in each lg phenylalanine should be less than 25EU. (For injection)
take this product about 0.13g, precision weighing, add anhydrous formic acid 3ml dissolved, add glacial acetic acid 50ml, according to the potential titration method (General rule 0701), with high gas acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of hydrochloric acid titration solution (0.1 mol/L) corresponds to 16.52mg of C9H1N02.
amino acid drugs.
sealed storage.